Academic Profile

Academic Profile

Prof Ruedl Christiane

Associate Chair (Research), School of Biological Sciences
Professor, School of Biological Sciences

Email: ruedl@ntu.edu.sg
Prof Ruedl Christiane

Biography
Professor Ruedl obtained her Doctor of Philosophy in Biology from the University of Innsbruck (Austria) in 1991. After her postdoctoral appointment at the Institute for Experimental Pathology (University of Innsbruck, Austria), she joined 1996 the Basel Institute for Immunology (Basel, Switzerland) as an independent researcher leading her own scientific group. She joined 2001, as a scientific director, Cytos Biotechnology AG (Zuerich, Switzerland) before she was awarded 2004 the Marie Voegtlin Fellowship from Swiss National Science Foundation and moved to the University of Basel. In 2006, she joined Nanyang Technology University ’s School of Biological Sciences in Singapore as an Associate Professor in Immunology where she is currently leading her own research laboratory and teaching the Immunology undergraduate and graduate courses. In 2018 she was promoted to Full Professor and from January 2019 she is the Associate Chair for Research at the School of Biological Sciences.
Research Interests
The research of Professor Ruedl laboratory focuses on the complex myeloid cell family with particular emphasis on dendritic cells (DC) and macrophages. To untangle the role of DC and macrophage cell populations we have constructed a series of novel transgenic mouse strains that can be used to ablate specifically subsets of DC and macrophages in vivo, to define their developmental origins or to regulate cytokine/growth factor gene expression with doxycycline inducible repression. By exploiting these unique transgenic mouse strains, we are particular interested to elucidate the functional specialization of distinct subsets of macrophages and DCs in mediating protective immunity in different infection models, such as influenza and malaria, and in inflammatory conditions, such as gut inflammation. Furthermore, we also study the ontogeny, phenotype and functional contributions of different myeloid cell subpopulations in a preclinical tumor animal model as well as in adipose tissue during obesity development.


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Current Projects
  • Development of immune-modulatory RNAs to regulate RIG-I mediated antiviral immune response for therapy and vaccination
  • Development of immune-modulatory RNAs to regulate RIG-I mediated antiviral immune response for therapy and vaccination
  • Does microbiota drive the turnover of tissue-resident innate immune cells?
  • Dynamics, diversity and function of macrophages in adipose tissue
  • Immuno-metabolic crosstalk mediated by the mitochondrial translocator protein in obesity
  • New platform for pre-clinical interventional and drug discovery studies
  • Role of diverse communities of intratumoral myeloid cells in intestinal cancer
Selected Publications
  • Soncin I, Sheng J, Chen Q, Shihui Foo S, Duan K, Lum J, Zolezzi F, Karjalainen K and Ruedl C. (2018). The tumour microenvironment creates a niche for the self-renewal of tumour-promoting resident macrophages in colon adenoma. Nature Communications, 9(582), 1-13.
  • Lai SM, Sheng J, Gupta P, Renia L, Duan K, Zolezzi F, Karjalainen K, Newell EW and Ruedl C. (2018). Organ-specific fate, recruitment and refilling dynamics of tissue-resident macrophages during blood-stage malaria. Cell Reports, 25, 2935-3230.
  • Ng SL, Teo YJ, Setiagani YA, Karjalainen K and Ruedl C. (2018). Type 1 conventional CD103+ dendritic cells control effector CD8+ T cell migration, survival and memory responses during influenza infection. Frontiers in Immunology, 9, 3043.
  • Sheng J, Chen Q, Soncin I, Ng SL, Karjalainen K and Ruedl C. (2017). Discrete subset of monocyte-derived cells among typical conventional type 2 dendritic cells can efficiently cross present. Cell Reports, 21, 1203-1214.
  • Muzaki ARM, Tetlak P, Sheng J, Loh SC, Setiagani YA, Poidinger M, Zolezzi F, Karjalainen K and Ruedl C. (2016). Intestinal CD103+CD11b- dendritic cells restrain colitis via IFN-γ-induced anti-inflammatory response in epithelial cells. Mucosal Immunology, 9(2), 336-351.

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