Academic Profile

Academic Profile

Asst Prof Liu Quan

Assistant Professor

School of Chemical and Biomedical Engineering
College of Engineering

Phone: (+65)6316 8748
Office: N1.3-B2-10

  • PhD (Biomed Engrg) University of Wisconsin, Madison 2005
  • MSc (Biomed Eng) University of Wisconsin, Madison 2002
  • MS (Elect Engrg) Grad Sch of USTC & CAS, Beijing 1999
  • BS (Elect Engrg) Xi'dian University 1996
Dr. Quan Liu received the PhD degree in Biomedical Engineering from the University of Wisconsin, Madison. He is currently an assistant professor in the School of Chemical and Biomedical Engineering at Nanyang Technological University in Singapore. His research interest is focused on optical imaging and spectroscopy for medical diagnostics. Dr. Liu has published nearly forty journal papers and held twelve US patents/applications in the field of biomedical optics. He has also secured a total mount of external funding more than 3 million USD to support his group. Dr. Liu has served as a reviewer for several top journals, such as Optics Letters, Optics Express and Nature Communication, and multiple international funding agencies as well as a subcommittee member and session chair for multiple international conferences such as European Conferences in Biomedical Optics (ECBO) and Photonics West. Dr. Liu is a senior SPIE member and a regular OSA member.

Dr. Quan Liu and his group's research in biomedical optics, i.e. biophotonics, focus on developing "optical biopsy" methods based on optical imaging and spectroscopy including diffuse reflectance, fluorescence and Raman techniques. These methods can non-invasively characterize the pathological status of tissues for medical diagnostics to reduce or even remove the need of performing physical biopsies. This group aims to address fundamental challenges that prevent these techniques from being clinically applicable by developing novel optical methods and/or incorporating other complementary techniques such as elastography, nanotechnology enabled plasmonics and ultrasound imaging, in a purpose to enhance the capability of optical biopsy methods in the accuracy, the signal to noise ratio, the spatial resolution and multiplexing capability. We are also interested in looking at the therapeutic effect of laser enabled therapy in cancer and the identification of rare tumor cells with optical spectroscopy. In parallel to technical development, his group also performs translational research to transfer these powerful optical techniques from benchtop to beside.

For more information, please visit his group's homepage at
Research Interests
• Biophotonics
• Biomedical optical spectroscopy and imaging
• Non-invasive medical diagnostics
• Biomedical instrumentation
• Computer simulation of electromagnetic wave in tissue
Current Projects
  • A technique for focusing laser light though fog based on optical cavity
  • Depth profiling of Raman fingerprints to determine the state of wound healing
  • Hybrid Opthalmologic Raman Spectroscopy/ Optical Coherence Tomography
  • Investigation of depth sensitive Raman spectroscopy in skin wound healing assessment for optimal treatment
  • Multifunctional disposable microneedle preventing cross contamination
  • Parallel optical sectioning microscopy for 3D spectroscopic imaging
  • Real-time Decoding of Stimulus-evoked Pain Intensity from Spontaneous and Elicited Electroencephalography
Selected Publications
  • Manish Verma and Quan Liu. (2017). Evaluation of the optimal steepest ascent algorithm for focusing light through turbid media. European Conferences on Biomedical Optics (ECBO), Germany.
  • Ravi Kumar Kannadorai, Geraldine Giap Ying Chiew, Kathy Luo Qian and Quan Liu. (2015). Dual functions of gold nanorods as photothermal agents and autofluorescence enhancer to track cell death during plasmonic photothermal therapy. Cancer letters, 357(1), 152-159.
  • Malathi Mathiyazhakan, Yuanxiang Yang, Yibo Liu, Caigang Zhu, Q. Liu, Claus Dieter Ohl, Kam Chiu Tam, Yu Gao, Chenjie Xu. (2015). Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation. Colloids and Surfaces B: Biointerfaces, 126, 569-574.
  • Clement Yuen and Quan Liu. (2014). Hollow agarose microneedle with silver coating for intradermal surface enhanced Raman measurements: A skin-mimicking phantom study. Journal of Biomedical Optics, In Press.
  • Dong Wei, Shuo Chen and Quan Liu. (2014). Review of Fluorescence Suppression Techniques in Raman Spectroscopy. Applied Spectroscopy Reviews, In Press.

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