Academic Profile

Academic Profile

Prof Peter Preiser

Associate Vice President (Biomedical and Life Sciences), Nanyang Technological University
Professor, School of Biological Sciences

Email: prpreiser@ntu.edu.sg
Prof Peter Preiser

Biography
Prof Peter Preiser is the Associate Vice President (Biomedical & Life Sciences) and a Professor of Molecular Genetics & Cell Biology at the Nanyang Technological University (NTU). Before this he was Chair of the School of Biological Sciences for over six years. He obtained his Doctor of Philosophy in Biology from University of Delaware, USA, in 1981. After his postdoctoral appointment at Worcester Foundation for Experimental Biology, USA, Prof Preiser joined London’s National Institute for Medical Research as a Senior Research Scientist. In 2003 he left London to join NTU’s School of Biological Sciences (SBS) as an Associate Professor and was later promoted to full Professor in 2009.

His research interest focus on the molecular mechanisms by which the malaria parasite is able to avoid host immunity and adapt to changes in the host cell environment. He has extensive experience in malaria biology and developing quantitative proteomic approaches along with transcriptional profiling to understand complex biological processes in relation to host parasite interaction.

He is the co-Lead PI of the AMR inter-disciplinary research group with the Singapore-MIT Alliance for Research and Technology (SMART), Prof Preiser has collaborated with top research institutes around the world and has published over 100 top-quality international journal papers.

Prof Preiser has often been invited as an expert reviewer for numerous local/international funding agencies and international journals including Science, Nature, Nature Medicine, Proceedings of the National Academy of Sciences and so on. He serves on the scientific advisory board of the French Alliance for Parasitology and Health Care (ParaFrap) and has organised a number of international meetings in Singapore.
Research Interests
My research interests focus on the molecular mechanisms by which the malaria parasite is able to avoid host immunity and adapt to changes in the host cell environment. One of the main problems in developing an efficient malaria vaccine is the ability of the parasite to evade host immune responses. Immune evasion happens both at the level of the infected red blood cell and at the process of invasion, the step at which the parasite infects a new cell.

A key focus area of the lab is to understand the mechanisms on how the malaria merozoite recognizes and penetrates the erythrocyte. To address these questions we have particular focused on the role of the Reticulocyte Binding Protein Homologues (RH) family of proteins which is found in all malaria species and has been implicated on playing a role in immune evasion and parasite virulence. Using both the human parasite Plasmodium falciparum as well as the rodent parasite P. yoelii we have been able to address question relating to mechanisms regulating parasite virulence as well as getting a cleared understanding on how these large proteins mediate their function. An interesting upshot of this work is the possibility of using them as part of a malaria vaccine formulation.

In addition to merozoite invasion the lab has also spend significant effort in elucidating the biological role of the STEVOR and PIR multigene families identified in P. falciparum and P. vivax respectively. While STEVOR is unique to P. falciparum the PIR multigene family is found not only in P. vivax, but also rodent and simian malaria parasites. My research group has focused on developing a range of reagents that allow us to address what the role of STEVOR is in parasite development. We have recently been able to show that STEVOR is important for immune evasion and plays a direct role in parasite mediated rosetting. The PIR gene family provides a unique opportunity to study antigenic variation in a rodent model and possibly utilize the information gained in this system to understand how these genes may work in the intractable human parasite P. vivax. Currently, our efforts focus on understanding how the pir genes are transcriptionally regulated.
At the same time my research group has expanded to also focus more on the host responses in relation to parasite infections. This has identified NK cells as critical in protecting the host from parasite induced virulence. In addition we have developed a wide range of omic tools to study the parasite in more detail. Using these platforms has provided new insights in P. vivax biology and has identified RNA modifications as an important regulator of gene expression.
Current Projects
  • A comprehensive survey of the interactome inside the cytoplasm of red blood cell infected by Plasmodium parasite
  • Biodegradable Cardiovascular Implants
  • Characterization of the STEVOR multigene family in the human malaria parasite Plasmodium falciparum
  • Community-Based Malaria Elimination Program
  • Comparative transcription analysis to identify novel targets for malaria intervention
  • Deciphering the Plasmodium epitranscriptome as a mechanism of translational control in human malaria parasites
  • Development of Scalable Bioinformatics Algorithms and Tools for Emerging Sequencing Technologies
  • Development of a Clinical Trial Phase I Candidate: A1 (Malaria drug)
  • Development of malaria antigen library : a tool for identification of correlates of protection use for identification of human correlates of a protection
  • Erythrocyte signalling during Plasmodium falciparum merozoite invasion
  • Functional and structural characterization of functional domains of the Reticulocyte Binding Proteins of Plasmodium during merozoite invasion
  • Functional genomic analyses of human malaria parasite resistance to artemisinin
  • Identification of Novel Chemotypes with Promising Activity Against Blood Stage Plasmodium Falciparum
  • Identification of malaria parasite genes important for virulence and survival in the natural host
  • Identifying a Laboratory Marker of Artemisinin Resistance
  • Molecular mechanisms driving the adaptation of Plasmodium knowlesi to humans
  • Monetary Academic Resources for Research
  • Physical Characterization of Elastic Properties of Malaria Infested Red Blood Cells
  • Rapid Cellulose-Based Serological and Diagnostic Tests for COVID-19
  • Role of Multigene Families in Adaptation and immune evasion fo the malaria parasite
  • Signaling during Plasmodium falciparum merozoite invasion
  • Target deconvolution of antimalarials using in vitro and in vivo models
  • Temporal analysis of processing of the Plasmodium falciparum Reticulocyte Binding Proteins Homologues during merozoite invasion
  • The role of RNA modifications in malaria parasite biology
  • Towards field malaria diagnosis based on surface enhanced Raman spectroscopy in a low-cost fluidic chip
  • Understanding Molecular Mechanism of Supradamal, a Novel Adamantanyl-Based Antimalarial Drug
  • Understanding the mechanism of splenic clearance of malaria infected red blood cells
  • Understanding the molecular basis of red blood cell selection by malaria merozoites
  • Understanding the role of the spleen in malaria pathogenesis
  • Unstanding the functional role of the STEVOR multigene family in the human parasite Plasmodium falciparum
  • Validation Of Diagnostic Tools For Detection Of G6PD Deficiency
  • Variant Surface antigens of Plasmodium chabaaudi as a model to study antigenic variation in P. vivax
  • Whole Plasmodium exportome: Identification of survival and virulence factors
Selected Publications
  • Baumgarten S, Bryant JM, Sinha A, Reyser T, Preiser PR, Dedon PC, Scherf A. (2019). Transcriptome-wide dynamics of extensive m(6)A mRNA methylation during Plasmodium falciparum blood-stage development. Nature Microbiology, 4(12), 2246-2259.
  • Hoo R, Bruske E, Dimonte S, Zhu L, Mordmüller B, Sim BKL, Kremsner PG, Hoffman SL, Bozdech Z, Frank M, Preiser PR. (2019). Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies. EBioMedicine, 48, 442-452.
  • Ng CS, Sinha A, Aniweh Y, Nah Q, Babu IR, Gu C, Chionh YH, Dedon PC, Preiser PR. (2018). tRNA epitranscriptomics and biased codon are linked to proteome expression in Plasmodium falciparum. Molecular Systems Biology, 14(10), e8009.
  • Ye W, Chew M, Hou J, Lai F, Leopold SJ, Loo HL, Ghose A, Dutta AK, Chen Q, Ooi EE, White NJ, Dondorp AM, Preiser P, Chen J. (2018). Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway. PLoS Pathogens, 14(10), e1007298.
  • Aniweh Y, Gao X, Hao P, Meng W, Lai SK, Gunalan K, Chu TT, Sinha A, Lescar J, Chandramohanadas R, Li HY, Sze SK, Preiser PR. (2017). P. falciparum RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC. Cellular Microbiology, .

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