| Academic Profile |
 | Asst Prof Fang Mingliang
Assistant Professor, School of Civil and Environmental Engineering
Email: mlfang@ntu.edu.sg
Asst Prof Fang Mingliang |
| Biography |
Dr. Fang began his training as an environmental analytical chemist, and have recently applied his skills towards interdisciplinary -omic research. During his graduate training with Dr. Heather M. Stapleton at Duke University (PhD, 2015, Durham, NC, US), he expanded expertise to several research fields including organic contaminant fate, human exposure measurements, xenobiotic metabolism, biomarker identification, and toxicological studies with emerging environmental contaminants. Between 2015 and 2016, he worked as a research associate at The Center for Metabolomics and Mass Spectrometry at The Scripps Research Institute (San Diego, California, US) with Dr. Gary Siuzdak. There, his research focused on the application of high-resolution mass spectrometry (HRMS)-based metabolomics to investigate metabolite and biological pathway perturbations in relation to disease conditions. In Dec 2016, he was employed as an assistant professor in the School of Civil and Environmental Engineering, Nanyang Technological University in Singapore.
For more details on Dr. Fang's research activities, please visit - www.mlfanglab.weebly.com |
| Research Interests |
High-resolution mass spectrometry based metabolomics and lipidomics
Fate and transport of emerging environmental contaminants
Human exposure and biomarker discovery
Nuclear-receptor related endocrine disruption by environmental contaminants
High-throughput bioassay application in the toxicity assessment
Effect-directed analysis to screen bioactive compounds in environmental mixtures |
| Current Projects |
- Autologous PKD iPSC-derived kidney organoids: a novel platform for personalized drug screening
- Autologous PKD iPSC-derived kidney organoids: a novel platform for personalized drug screening (sub-award)
- Bedside to bench and back again: evaluating Neisseria spp. as novel respiratory pathobionts using systems biology
- Bedside to bench and back again: evaluating Neisseria spp. as novel respiratory pathobionts using systems biology (sub-award)
- Biodiversity and Bioprospecting of Magnetotactic Bacteria - An Overlooked Biotechnological Resource in the Tropical Marine Environment of Singapore
- Development of Chemical Testing Protocols and Analysis of Pesticide and Repellent Products
- Long-Term Environmental Behaviour for Treated Incineration Bottom Ash
- Lung Organoids: A tool of the fourth industrial revolution to study COVID-19 pathogenesis
- Metabolomics-directed drug detoxification using a high-throughput hPSC-derived 3D kidney organoid platform
- Novel methods for assessing nano-microbiome interactions of ingested engineered nanomaterials: Towards safer-by-design, biocompatible nano-materials in food applications from the gut microbial perspective
- The Interaction between Emerging Organic Contaminants and Gut Microbiome: Implication on "Gut Green Chemistry" and Healthcare
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| Selected Publications |
- Brittney Beyer, Mingliang Fang (Co-first), Benjamin Sadrian, J. Rafael Montenegro-Burke, Warren Plaisted, Bernard P.C. Kok, Toru Kondo, Gary Siuzdak, Luke L. Lairson. (2017). An endogenous metabolite enhances the maturation of oligodendrocytes (In Press). Nature Chemical Biology, .
- Mingliang Fang, Julijana Ivanisevic, H. Paul Benton, Caroline H. Johnson, Michael E Kurczy, Gary J Patti, Linh T. Hoang, Winnie Uritboonthai, and Gary Siuzdak. (2015). Thermal Degradation of Small Molecules: A Global Metabolomic Investigation. Analytical Chemistry, .
- Mingliang Fang, Thomas F. Webster, and Heather M. Stapleton. (2015). Effect-Directed Analyis of Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ) ligands in Indoor Dust. Environmental Science & Technology, .
- Mingliang Fang, Thomas F. Webster, and Heather M. Stapleton. (2015). Activation of Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust. Environmental Science & Technology, .
- Fang ML, Webster TF, and Stapleton HM. (2015). Characterize the PPARγ Ligand Binding Potential of Several Major Flame Retardants, Their Metabolites, Indoor Dust and Bioactivated Dust. Environmental Health Perspectives, .
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