Academic Profile

Academic Profile

Prof Jimmy P Tam@James P Tam

Professor, School of Biological Sciences

Prof Jimmy P Tam@James P Tam

James P. Tam received his Ph.D. in University of Wisconsin, Madison and held professorial appointments at Rockefeller University, Vanderbilt University and The Scripps Research Institute. He received the Vincent du Vigneaud Award (1986), the Rao Makineni Award (2003) by American Peptide Society, and Ralph F. Hirschmann Award (2005) by The American Chemical Societyis.

He is the director of Drug Discovery Centre of Nanyang Technological University and the Double-degree program in Biomedical Science and Chinese Medicine. He was the founding dean of School of Biological Sciences.
Research Interests
His research work has focused on the design and development of therapeutics, particularly biologics and immunologics of anti-infectives and synthetic vaccines.
Current Projects
  • Activation and Regulation of Inflammasomes by Dengue Virus
  • Affinity LC/MS (WAC-MS) for Analysis and Design of Complex Molecular Libraries
  • Dissecting the Roles of Scaffolding Proteins in Ras Signaling Pathways
  • Finding Bioactives from Coffee Waste
  • Food Science Technology
  • Genome-wide RNAi screen and analysis of host factors in coronavirus replication
  • Herbalomic : Novel Approach for Fingerprinting and Authentication of Herbal Products
  • Herbalomics: Novel approach for fingerprinting and authentication of herbal products
  • Large-scale conversion of wastes to functional food and high-value products
  • Mechanism And Inhibition Of RNA Virus Replication
  • Mutation-resistant Antivirals
  • Natural Products, Food And Health
  • Peptide Ligase: Molecular Gluer for Proteins
  • Plant Biologics in Medicinal Herbs collected in Singapore
  • Selective contact-active antimicrobial bio-macromolecules
  • Synthesis, Biophysical Characterization and Delivery properties of novel peptides for integrin targeting in non viral gene delivery to cancer cells
  • Synzyme And Natural Products (SYNC)
  • U-Turning Proteases to Ligases: Mechanism, Engineering and Applications
Selected Publications
  • Loo, S., Kam, A., Xiao, T., & Tam, J. P. (2017). Bleogens: Cactus-Derived Anti-Candida Cysteine-Rich Peptides with Three Different Precursor Arrangements.. Frontiers in Plant science, 8.
  • Xinya Hemu, James P. Tam. (2017). Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin. Current Pharmaceutical Design, 23(46), 2131-2138.
  • Qiu, Yibo, Hemu, Xinya, Liu, Ding Xiang, Tam, James P. (2014). Selective Bi-directional Amide Bond Cleavage of N-Methylcysteinyl Peptide. European Journal of Organic Chemistry, 2014(20), 4370-4380.
  • Li X, Ren Y, Sorokin V, Poh KK, Ho HH, Lee CN, de Kleijn D, Lim SK, Tam JP, Sze SK. (2014). Quantitative profiling of the rat heart myoblast secretome reveals differential responses to hypoxia and re-oxygenation stress.. Journal of Proteomics, 98, 138-49.
  • Hao P, Ren Y, Tam JP, Sze SK. (2013). Correction of errors in tandem mass spectrum extraction enhances phosphopeptide identification. Journal of Proteome Research, 12(12), 5548-57.

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