Academic Profile

Academic Profile

Prof Isabella Saggio

Visiting Professor, School of Biological Sciences

Email: isabella.saggio@ntu.edu.sg
Phone:
Office: School of Biological Sciences (SBS)
Prof Isabella Saggio

Biography
Isabella Saggio received her graduation with laude in Genetics at Sapienza University (Rome, Italy). She obtained her PhD in 1994 performing a collaborative work between Sapienza University and the Merck Research Institute for Molecular Biology. She was EU postdoctoral fellow at Institut Gustave Roussy (Paris France). In 1998 she came back to Sapienza University, at first as Assistant Professor and then as Associate Professor of Genetics and Gene Therapy. She obtained full professor qualification in Genetics according to Italian national standards in 2017. I.S. has been member of the San Raffaele Science Park from 2003 to 2011, is part of National Research Council (CNR) since 2003, of the Italian Network for Laminopathies since 2016. I.S. coordinates international activities at Sapienza, including a 5-year cooperation agreement between Sapienza University and Nanyang Technological University, signed in 2016. She founded in 2006 a Master of Scientific Journalism to improve the relationships between researchers and public. In 2017 she co-founded a Master in memoriam of Paolo Bianco in Stem cell biology and genome editing. She was sabbatical fellow at Laenec University and Pasteur Institute in France, and at the Salk Institute in the U.S. She is currently appointed visiting professor at Nanyang Technological University in Singapore. She is independent P.I. since more than two decades as underlined by last co-authorships in her publication list and grant record. I.S. main research interests are gene therapy along with studies on telomeres, nuclear architecture and aging. I.S. activities are described on the site: www.saggiolab.com.
Research Interests
I. Saggio lab projects

-Gene therapy vectors
In the years we have been dealing with different viruses, including AAV, lentivirus, adenovirus and humanized phages. We use viral vectors for gene correction and disease modeling. Along with this we have been studying the properties of these viral vectors to understand their biology and possibly to design their amelioration.

-Telomeres and lamins in natural and pathological aging
We have characterized a new telomeric gene interacting with lamins named AKTIP. AKTIP properties put it at the crossroad of central aspects of human metabolism including DNA replication, nuclear architecture, telomeropathies, laminopathies and cancer. We’re studying the implication of this gene in the different metabolic pathways by up to date imaging, and in tube and in vivo biocellular analyses.

Collaborative projects

-Stem cell related bone disease
We collaborate with into a project aiming at modeling, studying and correcting the bone genetic disease fibrous dysplasia.

-Diabetes
We collaborate into projects for the understanding and development of therapeutic approaches of different forms of diabetes.

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