Academic Profile

Academic Profile

Assoc Prof Su I-Hsin

Associate Professor, School of Biological Sciences

Email: ihsu@ntu.edu.sg
Assoc Prof Su I-Hsin

Biography
Dr. Su earned her B.A. degree from National Taiwan University, then moved to Germany for her graduate studies, where she received a ‘Diplom’ in Biology and a Ph.D. in Immunology from the Institute for Genetics, University of Cologne. Following graduate school, she successfully completed her postdoctoral studies at The Rockefeller University, New York, USA, before relocating to Singapore to establish her own research group. She is currently a tenured Associate Professor at the School of Biological Sciences, Nanyang Technological University. Here, she maintains a research group of 5-8 people by means of competitive grant awards and have authored several highly-cited, peer-reviewed papers published in high-impact journals including Cell, Nature Immunology, Stem Cell, Genes & Development, the Journal of Experimental Medicine, and the Journal of Clinical Investigation. Her laboratory is interested in elucidating the molecular mechanisms leading to the functional regulation of immune cells and cancers. She also frequently serves as a reviewer for several international research journals and grant agencies.
Research Interests
In the biological system, most of the important cellular events, such as growth, survival, apoptosis, differentiation and migration are regulated by post-translational modifications. Aside from phosphorylation, protein methylation has emerged over the last decade as one of the major control mechanisms in protein function.

The most well-characterized protein lysine methyltransferases (PKMT) are histone methyltransferases. They target lysine side chain of histone tails and contribute to chromatin structure and epigenetic regulation of gene expression. For many years, lysine methylation was thought to be histone- and nucleus-specific. However, increasing number of non-histone proteins, such as p53, Rubisco, cytochrome c and yeast ribosome are identified to be lysine-methylated. Moreover, our previous study revealed a potential role of Ezh2, a PKMT and polycomb group protein, in the cytosolic cell signaling of T cells.

To further substantiate the function of Ezh2 in cytosol, we chose dendritic cell as a model system, due to its large cytosolic compartment and active cytoskeletal remodeling. Our recent result indicates while Ezh2 is dispensable for the generation of dendritic cells in vitro and in vivo, Ezh2 regulates the kinetics of cell adhesion through methylation of a cytoskeletal protein. Further characterization of this and other lysine-methylated proteins is a work in progress.

Protein sequence analysis also suggested that many uncharacterized SET-domain containing proteins are involved in lysine methylation. To determine functional significance of PKMT in the cytosol, we selected and characterized novel SET-domain proteins, which are localized predominately in the cytosol and play a potential functional role in lymphocytes. Given the substantial evidence showing the involvement of lysine methylation in cellular functions, the study of novel protein lysine methyltransferases is a promising research topic.
Current Projects
  • CY2002 CN Yang Scholars Programme Undergraduate Research Experience
  • Ezh2-regulated dendritic cell functions in health and disease
  • Function and physiological significance of Setd3 in immune responses
  • Functional Signifiance of the Ezh2-Vav1 Interaction in normal & tumor cells
  • Functional implication of cytoplasmic EZH2 in cancer stem cells
  • Functional significance of talin methylation in normal and tumor cells
  • Molecular characterization of UBR7-regulated cell adhesion and migration
  • The Role of Cytosolic Ezh2 in prostate cancer
  • The role of Polycomb Group Protein Ezh2 in immune Response of Dendritic cells
  • Transcriptional Regulation of Ezh2 Expression in Immune Cells and Lymphoma
  • Understanding mammalian microRNA biology in health and disease
Selected Publications
  • Lim, T. J. F., and Su, I. H. (2018). Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality.. Journal of Immunology, 201, 3651-3661.
  • Loh, J. T., Lim, T. J. F., Ikumi, K., Matoba, T., Janela, B., Gunawan, M., Toyama, T., Bunjamin, M., Ng, L. G., Poidinger, M., Morita, A., Ginhoux, F., Yamazaki, S., Lam, K. P., and Su, I. H. (2018). Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells. iScience, 10, 23-39.
  • Evrard, M., Kwok, I. W. H., Chong, S. Z., Teng, K. W. W., Becht, E., Chen, J. M., Sieow, J. L., Penny, H. L., Ching, G. C., Devi, S., Adrover, J. P. M., Li, J. L. Y., Liong, K. H., Tan, L., Poon, Z., Foo, S., Chua, J. W., Su, I. H., Balabanian, K., Bachelerie, F., Biswas, S. K., Larbi, A., Hwang, W. Y. K., Madan, V., Koeffler, H. P., Wong, S. C., Newell, E. W., Hidalgo, A., Ginhoux, F., and Ng, L. G. (2018). Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions.. Immunity, 48, 364-379.
  • Venkatesan, N., Wong, J. F., Tan, K. P., Chung, H. H., Yau, Y. H., Cukuroglu, E., Allahverdi, A., Nordenskiold, L., Goke, J., Geifman-Shochat, S., Lin, V. C. L., Madhusudhan, M. S., and Su, I. H. (2018). EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms.. Oncogene, 37, 461-477.
  • Neo WH., Yap K., Lee SH., Looi LS., Khandelia P., Neo SX., Makeyev E., Su I-H. (2014). MicroRNA miR-124 controls the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression. Journal of Biological Chemistry, 289(30), 20788–20801.

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