Academic Profile

Academic Profile

Assoc Prof Li Hoi Yeung

Associate Chair (Academic), School of Biological Science
Associate Professor, School of Biological Sciences

Email: hyli@ntu.edu.sg
Assoc Prof Li Hoi Yeung

Biography
Dec 2000 Ph.D. in Biochemistry, The Chinese University of Hong Kong
Aug 2000 – Dec 2004 Postdoctoral Fellow, Howard Hughes Medical Institute, Carnegie Institution of Washington, Baltimore, MD 21210, USA
Dec 2004 – Present Assistant Professor, School of Biological Sciences, Nanyang Technological University, Singapore
Research Interests
1. Regulation of mitotic catastrophe
2. Regulation of spindle assembly and chromosome segregation.
3. Production of the RanGTP gradient in vivo.
4. Functional study of the RanGTPase in cell cycle progression.
5. Regulation of RCC1 during apoptosis
Current Projects
  • A regulatory role of RanGTP in kinetochore-spindle microtubules attachment via Aurora B kinase during metaphase
  • Cell biology analysis and 3D computational modeling of the production of the localized RanGTP concentration and its role in mitotic progression
  • Development Of 3D Printing Platform For Skin Culture
  • Development of 3D organotypic culture of human cornea
  • Genomic Stability of Malaria Parasites during Intra-Erythrocytic Cycle
  • Interaction of Living Matter with Oxide Thin films: potential Materials to prevent Bacterial Attachment
  • Regulation of RCC1 and its roles in apoptosis
  • Regulation of mitotic progression by autophagy
  • Roles of Condensin in regulating mitotic catastrophe
  • Roles of Histone H3 phosphorylation at Serine 10 in nuclear pore complex assembly
  • Roles of RanGTP in the nuclear accumulatiion of Survivin and its impact on apoptosis
  • Understanding the crosstalk between energy metabolism and cell cycle progression
Selected Publications
  • Fung, W.T. Beyzavi, A., Abgrall, P., Nguyen, N.T., and Li, H.Y. (2009). Microfluidic platform for controlling the differentiation of embryoid body,. Lab on a Chip, 9(17), 2591-2595.
  • Ho, C.Y., Wong, C.H. and Li, H.Y. (2008). Perturbation of the chromosomal binding of RCC1, Mad2 and Survivin causes spindle assembly defects and mitotic catastrophe. Journal of cellular biochemistry, 105(3), 835-46.
  • Huang Y.F. Wu M. Li H.Y. (2008). Tumor suppressor ARF promotes non-classic proteasomal independent polyubiquitination of COMMD1. Journal of Biological Chemistry, In Press(In Press), in Press.
  • Li HY, Ng WP, Wong CH, Iglesias PA, Zheng Y. (2007). Coordination of Chromosome Alignment and Mitotic Progression by the Chromosome-Based Ran Signal. Cell Cycle, .
  • Vong, Q.P.Y., Cao, K., Li, H.Y., Iglesias, P., and Zheng, Y. (2005). Chromosome alignment and segregation regulated by ubiquitination of Survivin. Science, 310, 1499-1504.

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