Academic Profile

Academic Profile

Assoc Prof Koh Cheng Gee

Associate Chair (Faculty), School of Biological Sciences
Associate Professor, School of Biological Sciences

Assoc Prof Koh Cheng Gee

Dr. Koh Cheng Gee obtained her BSc(Hons) from the National University of Singapore and her PhD from the University of Cambridge, UK. She joined the School of Biological Sciences (NTU) in 2004 as Assistant Professor. She is currently Associate Professor and Associate Chair (Faculty) at the School of Biological Sciences.
Research Interests
Our laboratory is interested in the signal transduction events involving small GTPases of the Rho family, their regulators and effectors. These proteins play key roles in transducing extracellular stimuli into distinct responses including cell shape changes, cell motility, adhesion, cell division and phagocytosis. The emphasis of our current research is on the kinase PAK, its interacting protein PIX and a family of serine/threonine phosphataes of the PP2C family, POPXs.
Current Projects
  • Cell Microenvironment And Signaling
  • Characterization, in vitro and in vivo validation of local tropical herbs for colon cancer, stomach cancer and liver cancer prevention and treatment
  • Functional relationships between nutrient and diseases
  • Interaction of Living Matter with Oxide Thin films: potential Materials to prevent Bacterial Attachment
  • LIMK1 regulates centrosomal dynamics during mitosis
  • Post-translational modification and auto-inhibition in the regulation of cell adhesion promoting KIF3 kinesin motor complex
  • Regulation of Cell Signalling
  • Regulation of the Kinesin-2 Motor Complex by POPX2 phosphastase
  • Signal Transduction in Cancer Cells
  • The Regulation of Actin Cytoskeleton In Mouse Embryonic Stem Cells During Self Renewal and Differentiation
  • The Regulations of Actin Cytoskelenton in Embryonic Stem Cells
  • The challenge of real-time imaging of signaling pathways in embryonic stem cells : is mES cell pluripotency related to cadherin signaling and their epithelial-like behaviour?
  • The regulation of actin cytoskeleton and cellular functins by POPX2 and its partners
  • The regulation of cell motility, phagocytosis and macropinocytosis downstream of the Rho GTPase signalling pathways
  • The regulation of focal adhesions in embryonic stem cells
  • The regulatory pathways integrating the cortical actin network and spindle dynamics during early stages of mitosis
  • The roles of the phosphatase popx in the regulation of cell signalling and cell morphology
  • Understanding Wound Healing through Cell Signaling, Microenvironment and Secretome
Selected Publications
  • Singh P, Gan CS, Guo T, Sze SK and Koh CG. (2011). Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis. Proteomics, 11(14), 2891-2900.
  • Heng YW and Koh CG. (2010). Action Cytoskeleton Dynamics and the Cell Division Cycle. The International Journal of Biochemistry & Cell Biology, 42, 1622-1633.
  • Susila, A, Chan H, Loh AXW, HQ Phang, ET Wong, Tergaonkar V and Koh CG. (2010). POPX2 phosphatase regulates cancer cell motility and invasiveness. Cell Cycle, 9, 179-187.
  • Wong CH, Chan H, Ho CY, Lai SK, Chan KS, Koh CG* & Hoi-Yeung Li*. (2009). Apoptotic histone modification inhibits nuclear transport by regulating RCC1. Nature Cell Biology, 11, 36-45.
  • Xie Y, Tan EJ, Wee S, Manser E, Lim L, Koh CG. (2008). Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways. Journal of Cell Science, 121, 514-521.

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