Academic Profile

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Academic Profile

Assoc Prof Lim Sierin

Programme Chair (Healthy Society), Interdisciplinary Graduate School
Associate Professor

School of Chemical and Biomedical Engineering
College of Engineering

Email: SLIM@NTU.EDU.SG
Phone: (+65)6316 8966
Office: N1.3-B3-11

Education
  • PhD University of California, Los Angeles 2005
  • BS University of California, Los Angeles 2000
Biography
Sierin Lim is an associate professor of bioengineering and the Assistant Chair (Research) at the School of Chemical and Biomedical Engineering, Nanyang Technological University (NTU) Singapore. She earned her B.S. in Chemical Engineering and Ph.D. in Biomedical Engineering from University of California Los Angeles (UCLA) and did a postdoc at University of California Irvine Department of Chemical Engineering and Materials Science.
Her Bioengineered and Applied Nanomaterials Laboratory (BeANs Lab) at NTU focuses on the design and engineering of hybrid nano/microscale devices from biological parts by utilizing protein engineering as a tool for applications in medicine (therapeutics, diagnostics, and vaccine), energy, cosmetics, and food. She is the founding chair and advisor to the Biomedical Engineering Society (Singapore) Student Chapter and is one of the STEM ambassadors at Singapore Committee for UN Women. She is also serving on the editorial board of Frontiers in Bioengineering and Biotechnology and advisory board of biotechin.asia. In 2012 she received the Asia Pacific Research Networking Fellowship from the International Federation for Medical and Biological Engineering (IFMBE) and in 2013 the L’Oréal-UNESCO Singapore for Women in Science National Fellowship.
Research Interests
The rapid advancement of nanotechnology in the past decades results in developments of individual units that can be assembled to form hyrarchical systems with varying complexity. Our lab focuses on the design, engineering, and development of hybrid nano/microscale devices from biological parts by utilizing protein engineering as assembly tool towards future healthcare and sustainable earth.
Our primary foci are the applications of protein-based nanocapsules as molecular carriers in medicine (i.e. therapeutics, diagnostics, vaccines). Novel applications for these nanocapsules in food and cosmetics are being explored. Three protein nanocapsules with unique properties under investigation are E2, Ferritin, and Vault. The projects range from basic understanding the self-assembly mechanisms of these protein nanocapsules to their engineering to achieve desirable behaviors in vivo.
Leveraging on our expertise in biological engineering, we are expanding our research protfolio to include elucidation of the water desalination process in mangrove and bacterial cellulose production for the development of biomimetic membrane and wound dressings. Due to the interdisciplinary nature of our projects, we are working closely with scientists from the School of Biological Sciences (SBS), School of Materials Science (MSE), Nanyang Environment and Water Research Institute (NEWRI), A*STAR Institute of Materials Research and Engineering (IMRE), Singapore Immunology Network (SIgN), Singapore Bioimaging Consortium (SBIC), and Genome Institute of Singapore (GIS).
Current Projects
  • Biomimetic production of customizable bacterial cellulose through synthetic biology approach
  • Biomolecular Electronics Based on Ferritin
  • Common mechanisms promoting circulating tumour cell survival and chemoresistance
  • Developing "Smart" Topical Delivery System
  • Development of Protein-based Platform Technology to Enhance Magnetic Resonance Imaging
  • Development of a novel immunogenic RNA based vaccine adjuvant system with caged protein nanoparticles
  • Exploration of Protein Nanocage for Encapsulation of L'Oreal Bioactives and Their Bioavailability Characterizations on Skin Model
  • Investigating the Roles of Stromal and Endothelial Cells on Tumorigenesis of Hepatocellular Carcinoma in 3D co/tri-culture Systems
  • New Research Initiatives in Chemical and Bioengineering Areas
  • Tunable Display of siRNA on Protein Nanocapsules for the Management of Hyperpigmentation Skin Condition
Selected Publications
  • Bhaskar S, Lim S*. (2016). Engineering Protein Nanocages as Carriers for Biomedical Applications. NPG Asia Materials, .
  • Kumar KS, Pasula RR, Lim S, Nijhuis CA*. (2016). Long-Range Tunneling Processes across Ferritin-Based Junctions. Advanced Materials, 28(9), 1824-1830.
  • Sana B, Johnson E, Lim S*. (2015). The Unique Self-assembly/disassembly Property of Archaeoglobus fulgidus Ferritin and Its Implications on Molecular Release from the Protein Cage. Biochimica et biophysica acta - General Subjects, 1805(12), 2544-2551.
  • Bücheler J, Howard C**, de Bakker CJ, Goodall S, Jones ML, Win T, Peng T, Tan CH, Chopra A, Mahler S, Lim S*. (2015). Development of a Protein Nanoparticle Platform for Targeting EGFR Expressing Cancer Cells. Journal of Chemical Technology and Biotechnology, .
  • Perlaki CM, Lim S, Liu Q*. (2015). Polarized Raman Spectroscopy for Enhanced Quantification of Protein Concentrations in an Aqueous Mixture. Journal of Raman Spectroscopy, 46(9), 744-749.

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