Academic Profile

Academic Profile

Assoc Prof Peter Droge

Associate Professor, School of Biological Sciences

Email: pdroge@ntu.edu.sg
Phone: +65 63162809
Office: SBS 05N 20
Assoc Prof Peter Droge

Biography
please refer to http://www.sbs.ntu.edu.sg/Staff/pdroge/index.html for a biosketch
Research Interests
please refer to http://www.sbs.ntu.edu.sg/Staff/pdroge/index.html for a detailed description
Current Projects
  • Biochemical and functional analysis of the newly discovered DNA (dRP) lyase activity of proto-oncoproteins HIMGA : implications for genome stability in human neoplasias and stem cells
  • Cell reprogramming using a novel UTF1-tomato pluripotency reporter mouse
  • Construction of a comprehensive genome map of Z-DNA segments as real-time indicators for genetic activities in human Embryonic stem cells
  • Genome Engineering Through Site-Spectific Recombination
  • Molecular Targeting and Mechanism of Action of Ruthenium Anticancer Agents
  • Probing into the existence of a ribosome code
  • Reprogramming of human adult fibroblasts into an embryonic stem cell-like state
  • Structural Analysis of HMGA-DNA Complexes at Abasic Sites
  • Structural and functional analysis of the proto-oncogene and DNA architectural factor HMGA2 in human embryonic stem cells
  • λ site-specific genome editing tool
  • λ-integrase mediated site-specific transgenesis to provide cell-engineering service to the research clients
Selected Publications
  • Makhija H, Roy S, Hoon S, Ghadessy FJ, Wong D, Jaiswal R, Campana D, Dröge P. (2018). A novel λ integrase-mediated seamless vector transgenesis platform for therapeutic protein expression.. Nucleic Acids Research, 46(16), e99.
  • EYD Chua*, GE Davey*, CF Chin, P Droge, WH Ang, CA Davey. (2015). Stereochemical Control of Nucleosome Targeting by Platinum-Intercalator Antitumour Agents. Nucleic Acids Research, in press.
  • Z Adhireksan*, GE Davey*, P Campomanes, M Groessl, CM Clavel, H Yu, A Nazarov, CHF Yeo, WH Ang, P Droge, U Roethlisberger, PJ Dyson, CA Davey. (2014). Ligand Substitutions between Ruthenium-Cymene Compounds Can Control Protein versus DNA Targeting and Anticancer Activity. Nature Communications, .
  • Haojie Yu, Hong Hwa Lim, Natalia O. Tjokro, Padmapriya Sathiyanathan, Suchitra Natarajan, Tian Wei Chew, Thomas Klonisch, Steven D. Goodman, Uttam Surana & Peter Dröge. (2014). Chaperoning HMGA2 protein protects stalled replication forks in stem and cancer cells. Cell Reports, .
  • Kurt Pfannkuche, Heike Summer, Ou Li, Jürgen Hescheler and Peter Dröge. (2009). The high mobility group protein HMGA2: a co-regulator of global chromatin structure and pluripotency in stem cells?. Stem Cell Reviews, .

« Back to Research Directory

​​​​​​​​