Academic Profile

Academic Profile

Assoc Prof Luo Dahai

Associate Professor, Infection and Immunity, Lee Kong Chian School of Medicine
Associate Professor, Lee Kong Chian School of Medicine

Assoc Prof Luo Dahai

Academic Qualifications:
1. Bachelor of Science (Honours)
Nanyang Technological University (NTU), Singapore 2002 – 2006
2. Doctor of Philosophy
NTU, Singapore 2006 – 2010

Professional Qualification(s)/Membership(s):
1. Young Investigator The European Molecular Biology Organization (EMBO) 11/2017 – 10/2021
2. Member Singapore Center of Excellence of Global Virus Network 2018 – Present

Employment History:
1. Research Internship Novartis Institute for Tropical Diseases, Singapore 06/2006 – 05/2007
2. Project Officer School of Biological Sciences (SBS), NTU, Singapore 09/2007 – 04/2010
3. Postdoctoral Fellow Howard Hughes Medical Institute, Department of Molecular Cellular and Developmental Biology, Yale University, USA 05/2010 – 09/2013
4. Nanyang Assistant Professor LKCMedicine, NTU, Singapore 09/2013 – Present
Research Interests
My primary research interest is to understand the molecular events involved in the battle between host and pathogens, in particular between RNA viruses and humankind. I developed this interest after I started my graduate work and I further cultivated it during my postdoctoral training. Using various methods ranging from biochemistry, biophysics, structural biology, and cell biology, I successfully answered interesting and demanding questions in the fields of viral replication and host defense systems. I would like to further my research career to better understand the conflict between host and pathogens and improve the well-being of humankind. My lab’s research focuses on the following two interrelated directions: 1) RNA virus transcription, replication, and the generation of pathogenic RNA species; 2) Host defense mechanisms involved in pathogenic RNA sensing and processing. We would like to exercise molecular engineering targeting RNA and RNA-protein complexes to develop new methods and tools for research and therapies.
Current Projects
  • Define Molecular Basis of Transcription and Replication of Chikungunya Virus
  • Develop next generation antimicrobial ectolysins
  • Development of immune-modulatory RNAs to regulate RIG-I mediated antiviral immune response for therapy and vaccination
  • Dissecting the flavivirus replication complex for the discovery of antiviral inhibitors
  • Dissecting the flavivirus replication complex for thediscovery of antiviral inhibitors
  • Fighting for Better Survival: Viral RNA Biogenesis versus Host Defense
  • LKCMedicine Internal Grant 24
  • Provost’s Chair in Medicine (Luo Dahai)
  • Recreate dengue virus replication in E. coli
  • Start-Up Grant
  • Structural & Functional Studies of Chikungunya virus replication complex
  • Structural and Functional Characterization of Antiviral Protein Variants Generated via Intronic Polyadenylation
  • Structure Determination of NLRP6: Towards defining its unique role in innate immunity, microbiota, and homeostasis of the gut
  • Studying Zika virus pathogenesis and the development of therapeutics, in vitro cell culture model and mouse models that display various disease phenotypes
  • Targeting Dengue Non Structural Protein 3 and its EssentialInteractions With Small Molecules.
  • The Spike protein as a crucial tool to design of vaccines, ELISA- based diagnostics and therapeutics
Selected Publications
  • Law YS, Utt A, Tan YB, Zheng J, Wang S, Chen MW, Griffin PR, Merits A, Luo D. (2019). Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase. Proceedings of the National Academy of Sciences of the United States of America (PNAS), .
  • Tay, M. Y. F., Saw, W. G., Zhao, Y., Chan, W. K. K., Singh, D, Chong, Y., Forwood, J. K., Ooi, E. E., Grüber, G., Lescar, J., Luo, D., and Vasudevan, S. G. (2015). The C-terminal 50 amino acid residues of Dengue NS3 protein are important for NS3-NS5 interaction and viral replication. Journal of Biological Chemistry, 290, 2379-2394.

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