Academic Profile

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Academic Profile

Assoc Prof Pu Kanyi

Assistant Chair (Faculty), School of Chemical and Biomedical Engineering


School of Chemical and Biomedical Engineering
College of Engineering

Email: KYPU@NTU.EDU.SG
Phone: (+65)6513 8077
Office: N1.3-B2-05

Education
  • PhD (Chemical and Biomolecular Engrg) National University of Singapore 2011
  • MS (Polymer Chemistry and Physics) Fudan University 2007
  • BS (Polymer Science) East China University of Science & Tech 2004
Biography
Dr. Pu joined the School of Chemical and Biomedical Engineering (SCBE) at NTU as an Associate Professor in June 2015. Till now, he has published more than 60 journal papers, 2 book chapters and 6 patents. With a h-index over 39, his work has been highlighted by many world-renown scientific journals such as Nature Biotechnology, Nature Methods, and Cell Express el al.. He has won a number of awards for his creative work, including a young investigator travel award and several best poster awards.

Dr. Pu received his MS (2007) from Fudan University in China. He then came to Singapore and did his PhD (2011) at National University of Singapore. He moved to Stanford University School of Medicine for his postdoctoral study in 2011 under the supervision of Prof. Jianghong Rao and the directorship of Prof. Sanjiv Sam Gambhir in the molecular imaging program at Stanford (MIPS). As an active member of MIPS and Center for Cancer Nanotechnology Excellence and Translation (CCNE-T), he made significant contributions to polymer based imaging nanoprobes and technologies, such as photoacoustic imaging, chemiluminescence imaging and in vivo imaging of reactive oxygen and nitrogen species.
Research Interests
The board research objective in my group is to develop multifunctional platform technologies for understanding, detection and treatment of life-threatening diseases. Toward this goal, we will take an interdisciplinary approach that brings together organic chemistry, nanotechnology and molecular biology to synthesize functional polymers, polish their optoelectronic and biochemical properties, and shape them into smart and biocompatible nanoagents for advanced molecular imaging and amplified therapy.

(1) Molecular Imaging: Detection and monitoring of pathological processes in disease microenvironment at the molecular level for prognosis, diagnosis and therapeutic outcome assessment
(2) Chemical Biology: Design and synthesis of activatable imaging probes to uncover how reactive radical species modulate tumor metabolism, promote metastasis and angiogenesis, and foster drug resistance phenotypes
(3) Materials Science: Development of organic semiconducting nanomaterials with state-of-art imaging modalities such as photoacoustic imaging, near-infrared fluorescence imaging and bioluminescent imaging to improve imaging penetration depth and spatial resolution
(4) Biotechnology: Development of noninvasive high-throughput technologies for drug screening with a focus on real-time in vivo imaging of drug metabolism and evolution of drug-induced toxicity
Current Projects
  • Development of Smart Photoacoustic Nanoprobes to Image Reactive Oxygen Species in Tumor for In Vivo Drug Screening
  • Organic Semiconducting Nanoplatform for Moelcular Imaging and Amplified Therapy
  • Organic photonic nanoprobes for in vivo imaging of neurodegenerative diseases
Selected Publications
  • Yuyan Jiang, Paul Kumar Upputuri, Chen Xie, Yan Lyu, Lulu Zhang, Qihua Xiong, Manojit Pramanik, and Kanyi Pu. (2017). Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window. Nano Letters, 17, 4964–4969.
  • Yan Lyu, Dong Cui, He Sun, Yansong Miao, Hongwei Duan, Kanyi Pu*. (2017). Dendronized semiconducting polymer as photothermal nanocarrier for remote activation of gene expression. Angew Chem Int Ed Engl, 129, 9283-9287.
  • Yan Lyu, Chen Xie, Svetlana A. Chechetka, Eijiro Miyako, Kanyi Pu*. (2016). Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons. Journal of the American Chemical Society, 138, 9049-9052.
  • Qingqing Miao, Yan Lyu, Dan Ding, Kanyi Pu*. (2016). Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH. Advanced Materials, 28, 3662-3668.
  • Pu K, Shuhendler AJ, Jokerst JV, Mei J, Gambhir SS, Bao Z, Rao J. (2014). Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice. Nature Nanotechnology, 9, 233–239.

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