Academic Profile

Academic Profile

Assoc Prof Julien Lescar


Associate Professor

School of Biological Sciences
College of Science

Email: JULIEN@NTU.EDU.SG
Phone: (+65)69082208
Office: EMB-06-07

Education
  • PhD University of Paris XI 1993
  • MSc(Theoretical Phys) University of Paris XI 1989
  • BSc(Hons) Lycee Louis-le Grand Paris 1984
Biography
1.1 CURRICULUM VITAE

Lescar Julien
Born June 17th, 1966 in Paris
French citizenship
Married, 2 children



EDUCATION

1990-1993 Ph.D. (December 1993) Université Paris XI, Orsay
Thesis work performed at the Institut Pasteur, Paris

1989 Master Degree in Physics
1988 B. Sc. Degree in Physics


RESEARCH AND PROFESSIONAL EXPERIENCE




Since January 2002 School of Biological Science
Nanyang Technological University, Singapore
Assistant Professor (2002)
Associate Professor (2004)

Octobre 1999 Hired as a permanent Scientist (Chargé de Recherches) with C.N.R.S, Université Joseph Fourier, Grenoble

1997-1999 Post-Doctoral Research Fellow
ESRF-EMBL Joint Structural Biology Group, Grenoble.

1995-1996 Post-Doctoral Research Fellow, Institut Pasteur, Paris


1994 Post-Doctoral Research Fellow, Washington University School of Medicine, St Louis, USA.

1990-1993 DEA, Thèse
Département d’Immunologie. Institut Pasteur, Paris
Research Interests
Structural Biology
Infectious Diseases
Structure-Based Drug Design
Research Grant
  • A*STAR Biomedical Research Council (2016-) [by Singapore Immunology Network]
  • Academic Research Fund Tier 1 (2015-)
  • Academic Research Fund Tier 2 (2016-)
  • Academic Research Fund Tier 2 (2016-) [by National University of Singapore (NUS)]
  • National Medical Research Council (2015-)
Current Projects
  • A*STAR-led Zika Virus Consortium
  • Bioinspired Coacervation for Green Processing of Biomolecular Composites
  • Comparative studies of the structure and adhesion properties of the aLB2, aMb2, aXb2 integrin, and the crystallographic studies of the b2 and b3 integrin
  • Complexity in virus replication: How to copy genomic RNA information with a
  • Controlling biofilm dispersal by defined molecular switches
  • Coronavirus ribonucleocapsid assembly and its replicase enzymes : structure and function
  • Dengue NS4B Structure Study
  • Discovering inhibitors against the Dengue virus NS3 helicase and NS5 polymerase using a fragment-based approach aided by X-ray crystallography, N.M.R. and Surface Plasmon resonance
  • Dissecting the flavivirus replication complex for the discovery of antiviral inhibitors
  • Role of the Universally Conserved GTPase HflX in Mycobacterial Replication
  • Self-Assembly Mechanisms of 3D Protein-Based, Robust Marine Biopolymer
  • Structural, functional and immunological characterisation of a Plasmodium multigene family associated with the pathogenesis of cerebral malaria
  • Structure study of dengue NS4B and other non-structural proteins
  • The protein chemistry of integrin adhesion molecules
  • The use of a thermostable DNA/RNA dependent RNA polymerase for the large-scale synthesis of dsRNA and siRNAs pools for gene silencing
  • Towards the design of dengue virus antiviral inhibitors
  • Towards the design of specific anti-inflammatory drugs : Determination of the three dimensional structure of the TAK1 protein kinase using X-ray crystallography
  • Towards the rational design of antiviral inhibitors - x-ray crystallographic structural studies of proteins and enzymes from two RNA viruses that are important human pathogens
  • Understanding Molecular Mechanism of Supradamal, a Novel Adamantanyl-Based Antimalarial Drug
  • X-ray crystallographic studies to explore the detailed DNA/RNA unwinding mechanisms of the viral helicases from SARS and hepatitis C
Selected Publications
  • Alag R, Balakrishna AM, Rajan S, Qureshi IA, Shin J, Lescar J, Grüber G, Yoon HS. (2013). Structural Insights into Substrate Binding by PvFKBP35, a Peptidylprolyl cis-trans Isomerase from the Human Malarial Parasite Plasmodium vivax. Eukaryotic Cell, 12(4), 627-634.
  • Masayo Kotaka#, Rong Kong#, Insaf Qureshi, Qin Shi Ho, Huihua Sun, Chong Wai Liew, Lan Pei Goh, Peter Cheung, Yuguang Mu, Julien Lescar, and Zhao-Xun Liang. (2009). Structure and Catalytic Mechanism of the Thioesterase CalE7 in Enediyne Biosynthesis. Journal of Biological Chemistry, .
  • Rajamanonmani R, Nkenfou C, Clancy P, Yau YH, Shochat SG, Sukupolvi-Petty S, Schul W, Diamond MS, Vasudevan SG, Lescar J. (2009). On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes. Journal of General Virology, 90, 799-809.
  • Rajamanonmani R, Nkenfou C, Clancy P, Yau YH, Shochat SG, Sukupolvi-Petty S, Schul W, Diamond MS, Vasudevan SG, Lescar J. (2009). On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes. Journal of General Virology, 90, 799-809.
  • Lescar J, Luo D, Xu T, Sampath A, Lim SP, Canard B, Vasudevan SG. (2008). Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target. Antiviral Research, 80, 94-101.

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