Academic Profile

Academic Profile

Prof Jimmy P Tam@James P Tam

Professor, School of Biological Sciences

Email: jptam@ntu.edu.sg
Prof Jimmy P Tam@James P Tam

Biography
James P. Tam received his Ph.D. in University of Wisconsin, Madison and held professorial appointments at Rockefeller University, Vanderbilt University and The Scripps Research Institute. He received the Vincent du Vigneaud Award (1986), the Rao Makineni Award (2003) by American Peptide Society, and Ralph F. Hirschmann Award (2005) by The American Chemical Societyis.

He is the director of Drug Discovery Centre of Nanyang Technological University and the Double-degree program in Biomedical Science and Chinese Medicine. He was the founding dean of School of Biological Sciences.

http://jptam.sbs.ntu.edu.sg/
Research Interests
His research work has focused on the design and development of therapeutics, particularly biologics and immunologics of anti-infectives and synthetic vaccines.

http://jptam.sbs.ntu.edu.sg/
Current Projects
  • Activation and Regulation of Inflammasomes by Dengue Virus
  • Affinity LC/MS (WAC-MS) for Analysis and Design of Complex Molecular Libraries
  • Dissecting the Roles of Scaffolding Proteins in Ras Signaling Pathways
  • Finding Bioactives from Coffee Waste
  • Food Science Technology
  • Genome-wide RNAi screen and analysis of host factors in coronavirus replication
  • Herbalomic : Novel Approach for Fingerprinting and Authentication of Herbal Products
  • Herbalomics: Novel approach for fingerprinting and authentication of herbal products
  • Large-scale conversion of wastes to functional food and high-value products
  • Mechanism And Inhibition Of RNA Virus Replication
  • Mutation-resistant Antivirals
  • Natural Products, Food And Health
  • Peptide Ligase: Molecular Gluer for Proteins
  • Plant Biologics in Medicinal Herbs collected in Singapore
  • Selective contact-active antimicrobial bio-macromolecules
  • Synthesis, Biophysical Characterization and Delivery properties of novel peptides for integrin targeting in non viral gene delivery to cancer cells
  • Synzyme And Natural Products (SYNC)
  • U-Turning Proteases to Ligases: Mechanism, Engineering and Applications
Selected Publications
  • Hemu, X.; To, J.; Zhang, X.; Tam, J. P. (2020). Immobilized Peptide Asparaginyl Ligases Enhance Stability and Facilitate Macrocyclization and Site-Specific Ligation. Journal of Organic Chemistry, 85(3), 1504-1512.
  • Antony Kam, Shining Loo, Jing-Song Fan, Siu Kwan Sze, Daiwen Yang, James P Tam. (2019). Roseltide rT7 is a disulfide-rich, anionic, and cell-penetrating peptide that inhibits proteasomal degradation. Journal of Biological Chemistry, 294(51), 19604-19615.
  • Qingling Ouyang, Xueling Feng, Shuangyang Kuang, Nishtha Panwar, Peiyi Song, Chengbin Yang, Guang Yang, Xinya Hemu, Gong Zhang, Ho Sup Yoon, James P. Tam, Bo Liedberg, Guang Zhu, Ken-Tye Yong, Zhong Lin Wang. (2019). Self-powered, on-demand transdermal drug delivery system driven by triboelectric nanogenerator. Nano Energy, 62, 610-619.
  • Xinya Hemu, Abbas El Sahili, Side Hu, Kaho Wong, Yu Chen, Yee Hwa Wong, Xiaohong Zhang, Aida Serra, Boon Chong Goh, Dina A. Darwis, Ming Wei Chen, Siu Kwan Sze, Chuan-Fa Liu, Julien Lescar, and James P. Tam. (2019). Structural determinants for peptide-bond formation by asparaginyl ligases. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 116(24), 11737-11746.
  • Antony Kam, Shining Loo, James P Tam. (2019). Discovery of a Plant-derived Cell-penetrating Proteasome Inhibitor. Experiemental Biology 2019.

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