Academic Profile

Academic Profile

Prof Yoon Ho Sup

Research Director, Biomedical Sciences, School of Biological Sciences
Professor, School of Biological Sciences

Prof Yoon Ho Sup

Prof Yoon Ho Sup is Research Director (Biomedical Sciences) in the President's Office and Professor in the School of Biological Sciences at Nanyang Technological University (NTU), Singapore. He received his BSc from Seoul National University and MSc from Korea Advanced Institute of Science and Technology (KAIST), and PhD (Biochemistry & Molecular Biology) from the University of Chicago. Before joining NTU, he worked as a Research Scientist and Sr. Research Scientist at Abbott Laboratories, USA. He joined the School of Biological Sciences in February 2002 as one of the founding faculty members. Prof Yoon has done pioneering research in deciphering how the Pleckstrin homology (PH) domain recognizes phosphoinositides and understands the molecular mechanism of the pro-survival Bcl-2 family proteins and the biological role of molecular chaperones on the stability of the pro-survival proteins. Prof Yoon's current research programs focus on the structural plasticity of the anti-cell death proteins, roles of immunophilins in human diseases, the transcriptional activation mechanism of orphan nuclear receptors, and intrinsically disordered proteins in conformational disorders such as Parkinson's Disease.

Prof Yoon has published on the order of 100 journal papers in highly regarded journals. He has successfully secured multi-million dollar competitive extramural research grants from funding agencies, such as A*STAR-Biomedical Research Council, Ministry of Education, Singapore Cancer Syndicate, and Ministry of Health-National Medical Research Council. Prof Yoon's service contributions have been impeccable, serving in various roles and capacities. He served as Head of Chemical Biology and Biotechnology Division (2010-11) and Structural Biology and Biochemistry Division (2011-2014) and Director of Biosciences Research Centre at the School of Biological Sciences (2016- Feb 2018). He also served on several grant and award committees. He has been active in conference organization both locally and internationally and has rendered his service to the research community as a reviewer for various peer-reviewed journals. He is a Council Member of Asia Pacific Protein Association (APPA) and participating Principal Investigator of the Consortium for Functional Glycomics (CFG). Prof Yoon was the recipient of the Abbott Drug Discovery Impact Award 2000. Prof Yoon is currently an editorial board member of Frontiers in Oncology and Pharmacology. In July 2016, Prof Yoon was elected as a Fellow of The Royal Society of Chemistry (FRSC).
Research Interests
Apoptotic cell death mechanism; Molecular chaperones in cancer and neurodegenerative diseases; Nuclear receptor-ligand Interaction; Biomolecular NMR; Mitotic Kinases and histones; Structure-based drug design
Current Projects
  • Characterization and search for novel extracellular porteases in Bacillus subtilis for industrial use
  • In vitro and in vivo studies of Suprafenacine, a novel microtubule destabilizing anti-cancer drug
  • Nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin
  • Regulation of vaccinia-related kinase 1 (VRK1) by mH2A1.1, a histone H2A variant
  • Seeking Selective and Sensitive Ligands for Hemagglutinin of H7N9 Influenza Virus: A Potential Sugarcode-Based Diagnostic
  • Selective inhibitors of VRK1, a mitotic kinase
  • Targeting PGA1-Nurr1 pathway
  • The Spike protein as a crucial tool to design of vaccines, ELISA- based diagnostics and therapeutics
  • Toward development of a new class of anti-malaria drug : molecular characterization and three-dimensional structure determination of plasmodium falciparum FK506-binding protein 35 (PfFKPB35)
  • Understanding Molecular Mechanism of Supradamal, a Novel Adamantanyl-Based Antimalarial Drug
  • Validation of Nurr1 Ligands as Potential PD Therapeutics (Theme 5 - Experimental Therapeutics)
  • Validation of small molecule ligands for Nurr1
Selected Publications
  • Rajan, S., Jang, Y., Kim,C-H., Kim, W., Toh, H.T., Jeon, J., Song, B., Serra, A., Lescar, J., Yoo, J.Y., Beldar, S., Liu, X.W., Feitosa, M., Kim, Y., Hwang, D., Goh, G., Lim, K-L., Park, H.M., Lee, C.H., Oh, S.F., Petsko, G.A., Yoon, H.S. and Kim, K.S. (2020). PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nature Chemical Biology, 16, 876-886.
  • Tae-Yoon Park, Yongwoo Jang, Woori Kim, Joon Shin, Hui Ting Toh, Chun-Hyung Kim, Ho Sup Yoon, Pierre Leblanc and Kwang-Soo Kim. (2019). Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases. Scientific Reports, 9(1), 15559.
  • Prakash A, Shin J, Rajan S, Yoon HS. (2016). Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin.. Nucleic Acids Research, 44(4), 2909-25.
  • Kim CH, Han BS, Moon J, Kim DJ, Shin J, Rajan S, Nguyen QT, Sohn M, Kim WG, Han M, Jeong I, Kim KS, Lee EH, Tu Y, Naffin-Olivos JL, Park CH, Ringe D, Yoon HS, Petsko GA, Kim KS. (2015). Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 112(28), 8756-61.
  • Rajan S, Austin D, Harikishore A, Nguyen QT, Baek K, Yoon HS. (2014). Crystal structure of Plasmodium vivax FK506-binding protein 25 reveals conformational changes responsible for its noncanonical activity. Proteins, 82(7), 1235-1244.

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