Academic Profile

Academic Profile

Prof Subramanian Venkatraman

Chair, School of Materials Science & Engineering


School of Materials Science & Engineering
College of Engineering

Email: ASSUBBU@NTU.EDU.SG
Phone: (+65)6790 4259
Office: N4.1-02-05

Education
  • PhD Carnegie Mellon University 1981
  • MSc Indian Institute of Technology, Chennai 1976
  • BSc(Hons) Bangalore University 1974
Biography
Dr.Subbu Venkatraman has a PhD in Polymer Chemistry from Carnegie-Mellon University. He has spent about 15 years in biomedical R&D in the USA, working with various applications of polymeric biomaterials. He held a senior position in R&D at Alza Corporation prior to joining NTU as Associate Professor in 2000. Since then he has published extensively in the field of biomaterials, with a total of 130 publications, and a citation count of 1300+ and a h-index of 23. He also holds 20 issued US patents in biomaterials/drug delivery, and 5 of these have been translated into products. He is concurrently the Director of the Ocular Therapeutic Engineering Centre, as well as Dy Director of the Nanyang Institute of Technology in Health & Medicine, and works closely with clinicians from Singapore and world-wide.
Research Interests
Research is focussed on the applications of polymeric biomaterials in medicine. In particular, research areas include biodegradable stents, injectable drug delivery systems and gene delivery. Controlled release of drugs to the eye and the cardiovascular system are the primary end applications. Cancer therapy using "stealth" particles also forms a significant component of the research activities.
Research Grant
  • NTU Internal Funding (2017-) [by NTUitive Pte Ltd]
  • NTU Internal Funding – Nanyang Institute of Technology in Health & Medicine (NITHM) (2017-) [by Nanyang Institute of Technology in Health and Medicine (NITHM)]
  • NTU-NHG Ageing Research Grant (2014-2017)
  • NTU-NHG Metabolic Diseases Collaboration Grant (2015-2017)
  • National Medical Research Council (2013-2017) [by Singapore General Hospital]
  • National Medical Research Council (2016-2017) [by National Heart Centre]
  • National Medical Research Council (2016-2017) [by National Medical Research Council (NMRC)]
  • SMART-NTU Innovation Grant (2017-) [by SMART Innovation Centre]
  • Singapore Eye Research Institute – NTU Joint R&D (2016-) [by Singapore Eye Research Institute]
  • Singapore General Hospital (2016-) [by Singapore General Hospital]
  • Singapore General Hospital Research Grant (2013-2017) [by Singapore General Hospital]
  • Singapore Israel Industrial Research and Development Foundation (2016-) [by Singapore Israel Industrial Research and Development Foundation]
  • Start Up Grant (2014-)
Current Projects
  • A New Glaucoma Drainage Device with Sustained Drug Elution
  • A Swellable Drug Loaded Coating for Stents to Target Fibrosis-Induced Ureteral Stricture
  • A localized sustained delivery system for the management of common male patterned baldness
  • A new biodegradable, sustained-release drug delivery system in a rabbit model
  • Adventitial drug delivery using nanoparticles for treatment of Critical Limb Ischemia
  • Amaranth Medical 1
  • Amaranth Medical 2
  • Anti-fibrotic cellular encapsulation for diabetic therapy
  • Autonomous, Low Cost, Ultrasensitive Water Monitoring SystemFor Cyanotoxins Based On Ferromagnetic Particles
  • Biodegradable Cardiovascular Implants
  • Biodegradable Cardiovascular Implants: Biodegradable Elastomers
  • Biodegradable Cardiovascular Implants: Cell-Biomaterials Interactions II
  • Biodegradable Cardiovascular Implants: Surface Functionalization for Cell Growth
  • Biodegradable Shape Memory Foam Plug for Temporary Endovascular Embolization in Interventional Radiology
  • Biodegradeable stents for hemodialysis vascular access intervention
  • Biodegradeable stents for hemodialysis vascular access interventions
  • Bone-targeting Nanomedicine for Treating Osteomyelitis
  • Cardiovascular Cellular Delivery Systems: Natural and Synthetic
  • Controlled Drug Delivery From Core-Shell Nanofibers in Polymeric Matrices (NTU-Technion)
  • DDS
  • Developing "Smart" Topical Delivery System
  • Development and application of sustained drug release technology for the delivery of nucleic acid molecules for the prevention of post-operative scarring in glaucoma
  • Development of a nanocarrier drug delivery system for a novel anti-vascular endothelial growth factor (anti-VEGF) in the treatment of age-related macular degeneration
  • Development of novel bioabsorbable drug-eluting ventilation tube for chronic middle ear infection
  • Drug Delivery Systems for Glaucoma and Cornea
  • Drug Delivery Systems for Glaucoma and Cornea research collaboration with Singapore Eye Research Institute (SERI)
  • Drug Delivery for Eye Allergy
  • Drug-Eluting Balloons (DEB) Controlled Delivery through Nanoparticulate Coating
  • Dual Eye Drop Formulation To Suppress T Cell-Mediated Inflammation And Replenish Lipids In Dry Eye Disease
  • Early detection of central venous catheter-related bloodstream infection
  • Fully biodegradable drug eluting stents for hemodialysis vascular access interventions
  • Fundamental studies of Nanocarriers for Drug and Protein Delivery
  • In vitro studies of nanoliposomes encapsulated aspirin for treatment of diabetic retinopathy
  • Innovation and Entrepreneurship
  • Key technologies for developing microorganisms-derived hyaluronic acid for biomedical applications
  • Monetary Academic Resources for Research
  • Myopia-1: Sustained release formulation for atropine delivery
  • NANO-SORB: Thin Biodegradable PLLA Stent Material Using Nanocomposite Fillers
  • Nanostructured Hydrogels: Characterization & Applications
  • Nanostructured hydrogels for Cardiac Tissue Engineering
  • Nanotechnology to Diagnose, Prevent, and Treat Cardiovascular Disease
  • Novel drug delivery platform based on coated ureteral stents for reducing ureteral fibrosis and strictures
  • Novel sustained release drug delivery system for retinal diseases with application of nanotechnology for ocular pharmacotherapy
  • Nuclear Safety Science Summer School
  • Oral Insulin Delivery
  • PILOT ANIMAL STUDY ON THE FEASIBILITY AND BIOSAFETY OF A NOVEL BIODEGRADABLE POST-BIOPSY BREAST MARKER
  • Self-Expanding Biodegradable Heart Plug
  • Structural characterization of drugs/siRNA loaded nanoparticles by high resolution transmission electron microscopy
  • Synthesis and Characterization of Biodegradable Thermoplastic Elastomers
  • Tailored drug delivery platform for reducing ureteral fibrosis and strictures: Bilayer ureteral coated stents
  • The Regenerative Medicine Initiative in Cardiac Restoration Therapy Research Programme
  • Vesico-Urethral Connector
Selected Publications
  • Yingying Huang, Yee Shan Wong, Herr Cheun Anthony Ng, Freddy Y.C. Boey, Subbu Venkatraman. (2017). Translation in Cardiovascular Stents and Occluders: From Biostable to Fully-degradable. Bioengineering & Translational Medicine, XXX, Accepted (June 2017).
  • Rini Rachel Joseph, Dulcia Wei Ni Tan, Moreno Raja Miguel Ramon, Jayaganesh V Natarajan, Rupesh Agrawal, Tina T Wong, Subbu S Venkatraman. (2017). Characterization of liposomal carriers for the trans-scleral transport of Ranibizumab. Scientific Reports, .
  • G. C. T. Au-Yeung, U. Sarig, H. Sarig, T. Bronshtein, L. Baruch, A. Spizzichino, J. Bortman, F. Y. C. Boey, M. Machluf, S. S. Venkatraman. (2017). Restoring the native tissue biophysical properties through patch re-cellularization. Biomaterials Science, , Accepted.
  • Y. Efraim, H. Sarig, N. C. Anavy, U. Sarig, E. de Berardinis, S. Y. Chaw, M. Krishnamoorthi, J. Kalifa, H. Bogireddi, T. V.Duc, T. Kofidis, L. Baruch, F. Y. C. Boey, S. S. Venkatraman, M. Machluf. (2017). Biohybrid Cardiac ECM-Based Hydrogels Improve Long Term Cardiac Function Post Myocardial Infarction. Acta Biomaterialia, 50, 220-233.
  • Ang HY, Bulluck H, Wong P, Venkatraman SS, Huang YY, Foin N. (2017). Bioresorbable stents: current and upcoming bioresorbable technologies. International journal of cardiology , 228, 931-939.

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