Academic Profile

Academic Profile

Asst Prof Chen Albert I-Ming


Assistant Professor

School of Biological Sciences
College of Science

Email: ALBERT.CHEN@NTU.EDU.SG
Phone: (+65)69082243
Office: CSB 12-01A-01

Education
  • PhD (Cellular, Molecular & Biomed Stud.) Columbia University 2006
  • MPhil Columbia University 2003
  • MA (Cellular, Molecular & Biomed Stud.) Columbia University 2002
  • BS (Liberal Arts & Sciences) Univ of Illinois at Urbana-Champaign 1997
Biography
Albert Chen is an assistant professor in the Warwick-NTU Neuroscience Program. He received his undergraduate degree from the University of Illinois and Ph.D. from Columbia University where he studied developmental neurobiology in the laboratory of Thomas Jessell. Albert was a postdoctoral fellow in the laboratory of Louis Reichardt at the University of California, San Francisco.
Research Interests
Albert Chen's research aims to identify and characterize factors that direct the assembly and maintenance of neural circuits, and to understand how the organization of these circuits controls specific behaviors. These general issues are examined through the analysis of circuits in the cerebellum important for coordination, movement and motor learning. His lab is exploring mechanisms underlying the development and function of cerebellar circuits using genetics, imaging, and behavioral approaches.
Research Grant
  • Academic Research Fund Tier 1 (2016-)
  • National Medical Research Council (2015-)
Current Projects
  • Exploring the link between Cadherin 13 and the organization and function of inhibitory neural circuits within the cerebellum
  • Neurotrophic factors and the assembly of inhibitory circuits in the cerebellum
  • The Role of Cadherin-13(CDH13) in the Development and Function of the Brain Circuitry and Its Implication for Autism Spectrum Disorders (ASDs)
Selected Publications
  • Zainolabidin, N., Kamath, S.P., Thanawalla, A.R., Chen, A.I. (2017). Distinct activities of Tfap2A and Tfap2B in the specification of GABAergic interneurons in the developing cerebellum. Frontiers in Molecular Neuroscience, 10(281).
  • Chen, A.I.*, Zang, K., Masliah, E., Reichardt, L.F. (2016). Glutamatergic axon-derived BDNF controls GABAergic synaptic differentiation in the cerebellum. Scientific Reports, 6(20201), *corresponding author.
  • Chen, A.I., Nguyen, C.N., Copenhagen, D.R., Badurek, S., Minichiello, L., Ranscht, B., Reichardt, L.F. (2011). TrkB (tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex. The Journal of Neuroscience, 31(8), 2769-80.
  • Chen, A.I., de Nooij, J.C., Jessell, T.M. (2006). Graded activity of transcription factor Runx3 specifies the laminar termination pattern of sensory axons in the developing spinal cord. Neuron, 49(3), 395-408.
  • Novitch, B.G., Chen, A.I., Jessell, T.M. (2001). Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron, 31(5), 773-789.

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