Academic Profile

Academic Profile

Asst Prof Chen Albert I-Ming

Assistant Professor

School of Biological Sciences
College of Science

Phone: (+65)69082243
Office: CSB 12-01A-01

  • PhD (Cellular, Molecular & Biomed Stud.) Columbia University 2006
  • MPhil Columbia University 2003
  • MA (Cellular, Molecular & Biomed Stud.) Columbia University 2002
  • BS (Liberal Arts & Sciences) Univ of Illinois at Urbana-Champaign 1997
Albert Chen is an assistant professor in the Warwick-NTU Neuroscience Program. He received his undergraduate degree from the University of Illinois and Ph.D. from Columbia University where he studied developmental neurobiology in the laboratory of Thomas Jessell. Albert was a postdoctoral fellow in the laboratory of Louis Reichardt at the University of California, San Francisco.
Research Interests
Albert Chen's research aims to identify and characterize factors that direct the assembly and maintenance of neural circuits, and to understand how the organization of these circuits controls specific behaviors. These general issues are examined through the analysis of circuits in the cerebellum important for coordination, movement and motor learning. His lab is exploring mechanisms underlying the development and function of cerebellar circuits using genetics, imaging, and behavioral approaches.
Current Projects
  • Control of discrete and rhythmic movement by cerebello-thalamo-cortical circuits
  • Defining the brain circuitry defects that cause dementia
  • Exploring the link between Cadherin 13 and the organization and function of inhibitory neural circuits within the cerebellum
  • Neurotrophic factors and the assembly of inhibitory circuits in the cerebellum
  • The Role of Cadherin-13(CDH13) in the Development and Function of the Brain Circuitry and Its Implication for Autism Spectrum Disorders (ASDs)
  • Warwick-NTU Neuroscience Research @ Singapore (WN2R@S) On Opto-Genetic Tools For Investigating Glial Cell Biology(Principal Investigators: Asst Prof Albert I. Chen and AsstProf Ayumu Tashiro)
Selected Publications
  • Kamath, S.P. and Chen, A.I. (2018). Myocyte enhancer factor 2c regulates dendritic complexity and connectivity of cerebellar Purkinje cells. Molecular Neurobiology, s12035, 1-18.
  • Tan, S., Xiao, Y., Yin, H.H., Chen, A.I., Soong, T.W., Je, H.S. (2018). Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. Proceedings of the National Academy of Sciences of the United States of America (PNAS), pnas.1812083115.
  • Low, A.Y.T.*, Thanawalla, A.R.*, Yip, A.K.K.*, Kim, J., Wong, K.L.L., Tantra, M., Augustine, G.J. and Chen, A.I. (2018). Precision of discrete and rhythmic forelimb movements requires a distinct neuronal subpopulation in the interposed anterior nucleus. Cell Reports, 22(9), 2322-2333. *these authors contributed equally.
  • Tantra, M.*, Guo, L.*, Kim, J., Zainolabidin, N., Eulenburg, V., Augustine, G.J., Chen, A.I. (2018). Conditional deletion of Cadherin-13 perturbs Golgi cells and disrupts social and cognitive behaviors. Genes, Brain and Behavior, e12466, *these authors contributed equally.
  • Zainolabidin, N., Kamath, S.P., Thanawalla, A.R., Chen, A.I. (2017). Distinct activities of Tfap2A and Tfap2B in the specification of GABAergic interneurons in the developing cerebellum. Frontiers in Molecular Neuroscience, 10(281).

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