Research Categories

Interface of Biology and Engineering (Engineering in Biology)

NameResearch Interests
Assoc Prof Ali MiserezStructural properties of biological materials from the macro-scale to the nano-scale Multi-scale structural and mechanical properties of biological materials, including biominerals. Elastomeric and structural properties of bioelastomers Protein chemistry of sclerotized hard-tissues from marine organisms, such as Cephalopod Single-molecular force spectroscopy of structural and elastic proteins Underwater adhesion mechanisms of adhesive proteins Biofouling RNA-sequencing and proteomics of extra-cellular biological materials Advanced Metal/Ceramic composites Experimental Fracture Mechanics
Assoc Prof Ang Wei Tech- BioRobotics / Bio-Mechatronics - Rehabilitation Engineering - Assistive Technology - Robotic Microsurgery - Robotic Cell Micromanipulation
Assoc Prof Arindam BasuLow-power Reconfigurable Mixed-signal design, Neural recording systems, Computational neuroscience, Nonlinear dynamics, Smart sensors for hearing-aids/ultrasound etc, Neuromorphic VLSI
Prof Atsushi GotoPolymer Chemistry and Polymer Materials 1) Controlled syntheses of polymers 2) Development of new living radical polymerization via organic catalysis 3) Creation of new advance polymer materials using structurally controlled polymers
Prof Bo Gunnar LiedbergThe research interests of Prof. Bo Liedberg can be divided into three main areas Surface Chemistry and Self Assembled Monolayers This part of the research concerns fundamental studies of adsorbates and ultrathin molecular architectures, like Self-Assembled Monolayers (SAMs), on solid supports. The group was very early in studying self-assembly of substituted alkylthiols on gold substrates. A key activity has been to study temperature driven phenomena occurring in such assemblies as well as in adsorbed layers on top such SAMs. Oligo(ethylene glycol) and oligosaccharide SAMs have attracted considerable attention, both experimentally and theoretically, because of their structural characteristics and advantageous properties in contact with biofluids. Another area concerns interfacial water and ice. Temperature programmed studies have been undertaken to improve the understanding of the nucleation and microscopic wetting behavior of water/ice. The complexity of the SAMs has increased over the years and we are today focusing on architectures based on SAMs bearing multivalent chelator heads, helix-loop-helix polypeptides and receptor functions. Bioinspired and Biomimetic Nanoscience This research concerns the development of nanoscale architectures fabricated using either top-down or bottom-up protocols (or a combination of both). We are, for example, developing plasmonic arrays based on 100 nm gold nano dots on silicon and glass surface for amplification of optical fluorescence signals, so-called metal enhanced fluorescence (MEF). We are also developing composite materials based on a combination of de novo designed peptide scaffolds, planar surfaces and nanoparticles of controlled size and shape. A novel concept based on peptide folding has been used for controlled assembly of gold nanoparticles. The group is also involved in the development of Dip Pen Nanolithography (DPN) for patterning of surfaces on the 30-100 nm length scale. This work is performed jointly with a previous student of the group who nowadays is setting up a nanolaboratory at the Institute of Physics, Vilnius. We are also involved in several EC projects where different types of micro- and nanoscale patterning tools are employed for production of coatings for biofouling, sensing and biomedical applications. Optical Biosensors, micro- and nanoarrays The group has a long experience in developing optical transducers for biosensing application. We were the first to demonstrate the use of surface plasmon resonance for studies of bioaffinity interactions at surfaces, a technology that today form the backbone in SPR/Biacore instruments developed for biospecific interaction analysis (BIA). We are today using it in combination with ellipsometric interrogation and imaging optics for microarraying, and in combination with nanoparticle for studies optical enhancement phenomena. This includes, for example, microarray chips for protein multiplexing. The group is also working on the development of generic biochips for studies of ligand-receptor binding. Besides working on microarray fabrication for protein detection and analysis we are also developing biochips for the safety and security area. Selected publications 1. Tinazli, A., Tang, J., Valiokas, R., Picuric, S., Lata, S., Piehler, J., Liedberg, B., Tampe, R., Chem. Eur. J. 11, 5249-5259 (2005). 2. Aili, D., Enander, K., Tai, F-I., Baltzer, L., Liedberg, B., Angew. Chem., 120, 5636-5638 (2008). 3. Aili, D., Enander, K., Baltzer, L., Liedberg, B., Nano Letters, 8, 2473-2478 (2008). 4. Andersson, O., Ulrich, C., Björefors, F., Liedberg, B., Sensors&Actuators B: Chemical, 134, 545-550 (2008). 5. Klenkar, G., Liedberg, B., Anal. Bioanal. Chem. 391, 1679-1688 (2008). 6. Aili, D., Selegård. R., Baltzer, L., Enander, K., Liedberg, Small, 5, 2445-2452 (2009). 7. Lee, H.-H., Ruzele, Z., Malysheva, L., Onipko, A., Gutes, A., Björefors, F., Valiokas, R., Liedberg, B., Langmuir, 25(24), 13959–71 (2009).
Assoc Prof Cai YiyuHis interest in Interactive & Digital Media (IDM) mainly includes Tactile/Haptic VR System Design, GPU-accelerated Digital Media Processing, Serious Games and Simulation, and Computer-aided Design. He has been doing research in the intersection of IDM, and Bio & Medical Sciences covering from Computer-assisted Surgery to Volumetric Cellular Image Processing to Phase I/II Drug Clinical Trial Design to Protein Docking. In MedTech field, he pioneered the research and development on Cardiovascular and Intracardiac Interventional Simulation for pre-treatment planning and training application. He is also active in industry-oriented research working closely with Engineering and Education sectors.
Assoc Prof Cao BinBiofilms in natural and engineered systems Biofilm-mediated environmental bioprocesses Biofilm biology-informed biofilm engineering Biofilm-enabled biotechnological applications
Prof Chan Bee Eng, MaryHer main research interests are in polymers in nanoscience and biotechnology. She has published extensively, with more than 240 papers in top-tier journals. She is a leader in the field of antibacterial and antibiofilm polymers. Her group has invented a new class of potent cationic antimicrobial polymers which are non-toxic and biocompatible. Her antibacterial polymers are more environmentally friendly than current disinfectives and are being applied as device coatings and solutions to fight the global Antimicrobial Resistance (AMR) public health crisis. These new antimicrobial polymers have been reported in Angewandte Chemie (2020), Chemical Science (2020), Nature Communications (2019), Nano Letters (2018), ACS Nano (2015), Advanced Materials (2012) and Nature Materials (2011). Her polymers are explored for human and animal infections. The key inventions of Mary include glycosylated block co-beta-peptides that can eradicate biofilm and persister bacteria that are not easily treatable by classical antibiotics and which are the cause of recurrent infections. She also invented a series of polyimidazoliums that have antibiotic-like properties and ultra-high selectivity window, so that these can be exploited in complex consumer care products. She pioneered microporous antibacterial hydrogels that kill bacteria through acting as an anion sponge. These hydrogel coatings have been applied to contact lens and wound dressing Her patents have been used by/licensed to companies. Professor Mary Chan contributes actively to the industry through industry cooperation projects, consultancy and licensing of her technologies.
Prof Chen Wei Ning, William1. Food Waste Management; 2. Food Processing Tech Innovations; 3. Metabolic and Microbial Engineering for Valuable Chemicals; 4. Sustainable Production of Food Ingredients; 5. Fermentation Technology; 6. Biomarkers Identification for Nutrition and Food Safety
Prof Chen XiaodongCurrently, Prof. Chen's research focuses on two directions: (1) Integrated nano-bio interface: to develop programmable nanostructure-biomaterial hybrid systems for monitoring, manipulating, and mimicking biological processes. (2) Programmable materials for energy conversion: to explore programmable modules for electrochemical energy conversion and storage.