|Assoc Prof Ali Gilles Tchenguise Miserez||Structural properties of biological materials from the macro-scale to the nano-scale
Multi-scale structural and mechanical properties of biological materials, including biominerals.
Elastomeric and structural properties of bioelastomers
Protein chemistry of sclerotized hard-tissues from marine organisms, such as Cephalopod
Single-molecular force spectroscopy of structural and elastic proteins
Underwater adhesion mechanisms of adhesive proteins
RNA-sequencing and proteomics of extra-cellular biological materials
Advanced Metal/Ceramic composites
Experimental Fracture Mechanics
|Assoc Prof Ang Wei Tech||- BioRobotics / Bio-Mechatronics
- Rehabilitation Engineering
- Assistive Technology
- Robotic Microsurgery
- Robotic Cell Micromanipulation
|Assoc Prof Arindam Basu||Low-power Reconfigurable Mixed-signal design, Neural recording systems, Computational neuroscience, Nonlinear dynamics, Smart sensors for hearing-aids/ultrasound etc, Neuromorphic VLSI
|Assoc Prof Atsushi Goto||Polymer Chemistry and Polymer Materials
1) Controlled syntheses of polymers
2) Development of new living radical polymerization via organic catalysis
3) Creation of new advance polymer materials using structurally controlled polymers
|Prof Atul N. Parikh||Membrane biophysics
biologically inspired materials
synthetic chemical biology
|Prof Bo Gunnar Liedberg||The research interests of Prof. Bo Liedberg can be divided into three main areas
Surface Chemistry and Self Assembled Monolayers
This part of the research concerns fundamental studies of adsorbates and ultrathin molecular architectures, like Self-Assembled Monolayers (SAMs), on solid supports. The group was very early in studying self-assembly of substituted alkylthiols on gold substrates. A key activity has been to study temperature driven phenomena occurring in such assemblies as well as in adsorbed layers on top such SAMs. Oligo(ethylene glycol) and oligosaccharide SAMs have attracted considerable attention, both experimentally and theoretically, because of their structural characteristics and advantageous properties in contact with biofluids. Another area concerns interfacial water and ice. Temperature programmed studies have been undertaken to improve the understanding of the nucleation and microscopic wetting behavior of water/ice. The complexity of the SAMs has increased over the years and we are today focusing on architectures based on SAMs bearing multivalent chelator heads, helix-loop-helix polypeptides and receptor functions.
Bioinspired and Biomimetic Nanoscience
This research concerns the development of nanoscale architectures fabricated using either top-down or bottom-up protocols (or a combination of both). We are, for example, developing plasmonic arrays based on 100 nm gold nano dots on silicon and glass surface for amplification of optical fluorescence signals, so-called metal enhanced fluorescence (MEF). We are also developing composite materials based on a combination of de novo designed peptide scaffolds, planar surfaces and nanoparticles of controlled size and shape. A novel concept based on peptide folding has been used for controlled assembly of gold nanoparticles. The group is also involved in the development of Dip Pen Nanolithography (DPN) for patterning of surfaces on the 30-100 nm length scale. This work is performed jointly with a previous student of the group who nowadays is setting up a nanolaboratory at the Institute of Physics, Vilnius. We are also involved in several EC projects where different types of micro- and nanoscale patterning tools are employed for production of coatings for biofouling, sensing and biomedical applications.
Optical Biosensors, micro- and nanoarrays
The group has a long experience in developing optical transducers for biosensing application. We were the first to demonstrate the use of surface plasmon resonance for studies of bioaffinity interactions at surfaces, a technology that today form the backbone in SPR/Biacore instruments developed for biospecific interaction analysis (BIA). We are today using it in combination with ellipsometric interrogation and imaging optics for microarraying, and in combination with nanoparticle for studies optical enhancement phenomena. This includes, for example, microarray chips for protein multiplexing. The group is also working on the development of generic biochips for studies of ligand-receptor binding. Besides working on microarray fabrication for protein detection and analysis we are also developing biochips for the safety and security area.
1. Tinazli, A., Tang, J., Valiokas, R., Picuric, S., Lata, S., Piehler, J., Liedberg, B., Tampe, R., Chem. Eur. J. 11, 5249-5259 (2005).
2. Aili, D., Enander, K., Tai, F-I., Baltzer, L., Liedberg, B., Angew. Chem., 120, 5636-5638 (2008).
3. Aili, D., Enander, K., Baltzer, L., Liedberg, B., Nano Letters, 8, 2473-2478 (2008).
4. Andersson, O., Ulrich, C., Björefors, F., Liedberg, B., Sensors&Actuators B: Chemical, 134, 545-550 (2008).
5. Klenkar, G., Liedberg, B., Anal. Bioanal. Chem. 391, 1679-1688 (2008).
6. Aili, D., Selegård. R., Baltzer, L., Enander, K., Liedberg, Small, 5, 2445-2452 (2009).
7. Lee, H.-H., Ruzele, Z., Malysheva, L., Onipko, A., Gutes, A., Björefors, F., Valiokas, R., Liedberg, B., Langmuir, 25(24), 13959–71 (2009).
|Assoc Prof Cai Yiyu||His interest in Interactive & Digital Media (IDM) mainly includes Tactile/Haptic VR System Design, GPU-accelerated Digital Media Processing, Serious Games and Simulation, and Computer-aided Design.
He has been doing research in the intersection of IDM, and Bio & Medical Sciences covering from Computer-assisted Surgery to Volumetric Cellular Image Processing to Phase I/II Drug Clinical Trial Design to Protein Docking. In MedTech field, he pioneered the research and development on Cardiovascular and Intracardiac Interventional Simulation for pre-treatment planning and training application.
He is also active in industry-oriented research working closely with Engineering and Education sectors.
|Assoc Prof Cao Bin||Microbial biofilms in natural and engineered systems
Extracellular polymeric substances (EPS)
Interactions of biofilms and EPS with environmental contaminants
Biological treatment of waste/wastewater
Biodegradation, bioremediation, waste-to-energy (or value-added products) bioconversion
|Prof Chan Bee Eng, Mary||Dr Chan-Park has interest and expertise in nanoimprint, micro- and nano-patterning, biomaterials, tissue engineering and carbon nanotubes. She has published more than 80 journal papers and holds more than 15 patents/patent applications in these areas. She has supervised more than 12 PhD students and 15 postdoctoral fellows.
|Asst Prof Chen Gang||The overall goal of my research group is to employ cutting-edge biophysical techniques to better understand the structures and the physical-chemical properties of RNAs and RNA-ligand complexes to provide deeper insight into and to facilitate precise control of the diverse biological functions involving RNA. We aim to use the fundamental knowledge to fight neurodegenerative diseases, cancers, bacterial and viral infections by designing and discovering novel therapeutic ligands targeting RNA. To approach the challenging goals, we have assembled a multidisciplinary team with expertise ranging from molecular biophysics, structure biology, computation, chemical synthesis, cell biology, to medical healthcare. The research projects of current interests are:
(1) characterizing the molecular recognition interactions (e.g., hydrogen bonding and aromatic base stacking) accounting for structure, stability, and dynamics of RNA structural building blocks such as internal loops, hairpins, triplexes, and pseudoknots,
(2) probing the complex energy landscapes of RNA folding and assembly with protein,
(3) designing and discovering therapeutic ligands (small molecules, oligonucleotides, peptides, peptide nucleic acid, etc.) targeting RNA,
(4) developing nucleic acid based biosensors to rapidly detect toxic/pathogenic agents in food products and human body, and
(5) discovering and characterizing novel nucleic acid based catalysts for important organic and inorganic reactions at mild conditions.
We employ various conventional and cutting-edge biophysical and biochemical techniques including laser optical tweezers, NMR, UV-Vis, fluorescence, SPR, gel electrophoresis, PCR, chemical synthesis of modified oligonucleotides and peptides, in vitro transcription, protein expression, and cell culture assay. The research experience in the laboratory will help the students to grasp fundamental knowledge and experimental skills, to develop learning skills such as rigorous reasoning and innovative thinking, and to be able to ask and answer important questions within and beyond chemical and molecular sciences.
Selected Representative Publications:
Lihua Zhang, Hua Liu, Yong Shao,* Clement Lin, Huan Jia, Gang Chen,* Danzhou Yang,* Ying Wang, (2015) Selective Lighting Up of Epiberberine Alkaloid Fluorescence by Fluorophore-Switching Aptamer and Stoichiometric Targeting of Human Telomeric DNA G-quadruplex Multimer, Anal Chem, 87, 730-7
Gitali Devi,= Yuan Zhou,= Zhensheng Zhong,= Desiree-Faye Kaixin Toh,= and Gang Chen,* (2015) RNA Triplexes – From Structural Principles to Biological and Biotech Applications. Wiley Interdiscip Rev RNA, 6, 111-28. (= These authors contributed equally to this work)
Xing Ma,= Gitali Devi,= Qiuyu Qu, Desiree-Faye Kaixin Toh, Gang Chen,* Yanli Zhao,* (2014) Intracellular Delivery of Antisense Peptide Nucleic Acid by Fluorescent Mesoporous Silica Nanoparticles, Bioconjugate Chem, 25, 1412-20. (= These authors contributed equally to this work)
Gitali Devi, Zhen Yuan, Yunpeng Lu, Yanli Zhao,* and Gang Chen,* (2014) Incorporation of thio-pseudoisocytosine into triplex-forming peptide nucleic acids for enhanced recognition of RNA duplexes. Nucleic Acids Res, 42, 4008-18.
Yuan Zhou, Elzbieta Kierzek, Zi Ping Loo, Meraldo Antonio, Yin Hoe Yau, York Wieo Chuah, Susana Geifman-Shochat, Ryszard Kierzek,* and Gang Chen,* (2013) Recognition of RNA duplexes by chemically modified triplex-forming oligonucleotides. Nucleic Acids Res 41, 6664-73.
Tinoco, I., Jr., Chen, G., and Qu, X. (2010) RNA reactions one molecule at a time, in RNA Worlds, (Gesteland, R.F., Cech, T.R., and Atkins, J.F., Eds.), Cold Spring Harbor Labo