Research Categories

Interface of Biology and Engineering (Engineering in Biology)

NameResearch Interests
Assoc Prof Ali MiserezStructural properties of biological materials from the macro-scale to the nano-scale Multi-scale structural and mechanical properties of biological materials, including biominerals. Elastomeric and structural properties of bioelastomers Protein chemistry of sclerotized hard-tissues from marine organisms, such as Cephalopod Single-molecular force spectroscopy of structural and elastic proteins Underwater adhesion mechanisms of adhesive proteins Biofouling RNA-sequencing and proteomics of extra-cellular biological materials Advanced Metal/Ceramic composites Experimental Fracture Mechanics
Assoc Prof Ang Wei Tech- BioRobotics / Bio-Mechatronics - Rehabilitation Engineering - Assistive Technology - Robotic Microsurgery - Robotic Cell Micromanipulation
Assoc Prof Arindam BasuLow-power Reconfigurable Mixed-signal design, Neural recording systems, Computational neuroscience, Nonlinear dynamics, Smart sensors for hearing-aids/ultrasound etc, Neuromorphic VLSI
Assoc Prof Atsushi GotoPolymer Chemistry and Polymer Materials 1) Controlled syntheses of polymers 2) Development of new living radical polymerization via organic catalysis 3) Creation of new advance polymer materials using structurally controlled polymers
Prof Atul N. ParikhMembrane biophysics biologically inspired materials biosensors synthetic chemical biology
Prof Bo Gunnar LiedbergThe research interests of Prof. Bo Liedberg can be divided into three main areas Surface Chemistry and Self Assembled Monolayers This part of the research concerns fundamental studies of adsorbates and ultrathin molecular architectures, like Self-Assembled Monolayers (SAMs), on solid supports. The group was very early in studying self-assembly of substituted alkylthiols on gold substrates. A key activity has been to study temperature driven phenomena occurring in such assemblies as well as in adsorbed layers on top such SAMs. Oligo(ethylene glycol) and oligosaccharide SAMs have attracted considerable attention, both experimentally and theoretically, because of their structural characteristics and advantageous properties in contact with biofluids. Another area concerns interfacial water and ice. Temperature programmed studies have been undertaken to improve the understanding of the nucleation and microscopic wetting behavior of water/ice. The complexity of the SAMs has increased over the years and we are today focusing on architectures based on SAMs bearing multivalent chelator heads, helix-loop-helix polypeptides and receptor functions. Bioinspired and Biomimetic Nanoscience This research concerns the development of nanoscale architectures fabricated using either top-down or bottom-up protocols (or a combination of both). We are, for example, developing plasmonic arrays based on 100 nm gold nano dots on silicon and glass surface for amplification of optical fluorescence signals, so-called metal enhanced fluorescence (MEF). We are also developing composite materials based on a combination of de novo designed peptide scaffolds, planar surfaces and nanoparticles of controlled size and shape. A novel concept based on peptide folding has been used for controlled assembly of gold nanoparticles. The group is also involved in the development of Dip Pen Nanolithography (DPN) for patterning of surfaces on the 30-100 nm length scale. This work is performed jointly with a previous student of the group who nowadays is setting up a nanolaboratory at the Institute of Physics, Vilnius. We are also involved in several EC projects where different types of micro- and nanoscale patterning tools are employed for production of coatings for biofouling, sensing and biomedical applications. Optical Biosensors, micro- and nanoarrays The group has a long experience in developing optical transducers for biosensing application. We were the first to demonstrate the use of surface plasmon resonance for studies of bioaffinity interactions at surfaces, a technology that today form the backbone in SPR/Biacore instruments developed for biospecific interaction analysis (BIA). We are today using it in combination with ellipsometric interrogation and imaging optics for microarraying, and in combination with nanoparticle for studies optical enhancement phenomena. This includes, for example, microarray chips for protein multiplexing. The group is also working on the development of generic biochips for studies of ligand-receptor binding. Besides working on microarray fabrication for protein detection and analysis we are also developing biochips for the safety and security area. Selected publications 1. Tinazli, A., Tang, J., Valiokas, R., Picuric, S., Lata, S., Piehler, J., Liedberg, B., Tampe, R., Chem. Eur. J. 11, 5249-5259 (2005). 2. Aili, D., Enander, K., Tai, F-I., Baltzer, L., Liedberg, B., Angew. Chem., 120, 5636-5638 (2008). 3. Aili, D., Enander, K., Baltzer, L., Liedberg, B., Nano Letters, 8, 2473-2478 (2008). 4. Andersson, O., Ulrich, C., Björefors, F., Liedberg, B., Sensors&Actuators B: Chemical, 134, 545-550 (2008). 5. Klenkar, G., Liedberg, B., Anal. Bioanal. Chem. 391, 1679-1688 (2008). 6. Aili, D., Selegård. R., Baltzer, L., Enander, K., Liedberg, Small, 5, 2445-2452 (2009). 7. Lee, H.-H., Ruzele, Z., Malysheva, L., Onipko, A., Gutes, A., Björefors, F., Valiokas, R., Liedberg, B., Langmuir, 25(24), 13959–71 (2009).
Assoc Prof Cai YiyuHis interest in Interactive & Digital Media (IDM) mainly includes Tactile/Haptic VR System Design, GPU-accelerated Digital Media Processing, Serious Games and Simulation, and Computer-aided Design. He has been doing research in the intersection of IDM, and Bio & Medical Sciences covering from Computer-assisted Surgery to Volumetric Cellular Image Processing to Phase I/II Drug Clinical Trial Design to Protein Docking. In MedTech field, he pioneered the research and development on Cardiovascular and Intracardiac Interventional Simulation for pre-treatment planning and training application. He is also active in industry-oriented research working closely with Engineering and Education sectors.
Assoc Prof Cao BinMicrobial biofilms in natural and engineered systems Extracellular polymeric substances (EPS) Interactions of biofilms and EPS with environmental contaminants Biological treatment of waste/wastewater Biodegradation, bioremediation, waste-to-energy (or value-added products) bioconversion
Prof Chan Bee Eng, MaryDr Chan-Park has interest and expertise in nanoimprint, micro- and nano-patterning, biomaterials, tissue engineering and carbon nanotubes. She has published more than 80 journal papers and holds more than 15 patents/patent applications in these areas. She has supervised more than 12 PhD students and 15 postdoctoral fellows.
Asst Prof Chen GangThe overall goal of my research group is to employ cutting-edge biophysical techniques to better understand the structures and the physical-chemical properties of RNAs and RNA-ligand complexes to provide deeper insight into and to facilitate precise control of the diverse biological functions involving RNA. We aim to use the fundamental knowledge to fight neurodegenerative diseases, cancers, bacterial and viral infections by designing and discovering novel therapeutic ligands targeting RNA. To approach the challenging goals, we have assembled a multidisciplinary team with expertise ranging from molecular biophysics, structure biology, computation, chemical synthesis, cell biology, to medical healthcare. The research projects of current interests are: (1) characterizing the molecular recognition interactions (e.g., hydrogen bonding and aromatic base stacking) accounting for structure, stability, and dynamics of RNA structural building blocks such as internal loops, hairpins, triplexes, and pseudoknots, (2) probing the complex energy landscapes of RNA folding and assembly with protein, and (3) designing and discovering therapeutic ligands (small molecules, oligonucleotides, peptides, peptide nucleic acid, etc.) targeting RNA. We employ various conventional and cutting-edge biophysical and biochemical techniques including laser optical tweezers, NMR, UV-Vis, fluorescence, SPR, gel electrophoresis, PCR, chemical synthesis of modified oligonucleotides and peptides, in vitro transcription, protein expression, and cell culture assay. The research experience in the laboratory will help the students to grasp fundamental knowledge and experimental skills, to develop learning skills such as rigorous reasoning and innovative thinking, and to be able to ask and answer important questions within and beyond chemical and molecular sciences. Ru Ying Puah,= Huan Jia, = Manikantha Maraswami,= Desiree-Faye Kaixin Toh,= Rya Ero,= Lixia Yang, Kiran M. Patil, Alan Ann Lerk Ong, Manchugondanahalli S. Krishna, Ruimin Sun, Cailing Tong, Mei Huang, Xin Chen, Teck Peng Loh, Yong-Gui Gao, Ding Xiang Liu,* and Gang Chen,* (2018) Selective Binding to mRNA Duplex Regions by Chemically Modified Peptide Nucleic Acids Stimulates Ribosomal Frameshift. Biochemistry (Invited for a special issue of Future of Biochemistry), In press. Manikantha Maraswami, Sreekumar Pankajakshan, Gang Chen* and Teck-Peng Loh* (2017) Palladium-Catalyzed Direct C-H trifluoroethylation of aromatic amides, Org Lett, 19, 4223–4226 Hongzhong Chen, Huan Jia, Huijun Phoebe Tham, Qiuyu Qu, Pengyao Xing, Jin Zhao, Soo Zeng Fiona Phua, Gang Chen,* and Yanli Zhao,* (2017) Theranostic Prodrug Vesicles for Imaging Guided Co-Delivery of Camptothecin and siRNA in Synergetic Cancer Therapy, ACS Appl. Mater. Interfaces, 9, 23536–23543 Desiree-Faye Kaixin Toh,= Kiran M. Patil,= and Gang Chen,* (2017) Sequence-specific and selective recognition of double-stranded RNAs over single-stranded RNAs by chemically modified peptide nucleic acids (Invited Methods Article), J Vis Exp, In press, (= These authors contributed equally to this work). Zhensheng Zhong, Lixia Yang, Haiping Zhang, Jiahao Shi, Jeya Vandana, Do Thuy Uyen Ha Lam, René C. L. Olsthoorn, Lanyuan Lu, and Gang Chen* (2016) Mechanical unfolding kinetics of the SRV-1 gag-pro mRNA pseudoknot: possible implications for −1 ribosomal frameshifting stimulation, Sci Rep, 6, 39549. Toh, D.-F.,= Devi, G.,= Patil, K.M., Qu, Q., Maraswami, M., Xiao, Y., Loh, T.-P., Zhao, Y.,* and Chen, G.* (2016) Incorporating a guanidine-modified cytosine base into triplex-forming PNAs for the recognition of a C-G pyrimidine-purine inversion site of an RNA duplex. Nucleic Acids Res, 44, 9071-82 Jiazi Tan, Jia Xin Jessie Ho, Zhensheng Zhong, Shufang Luo, Gang Chen, and Xavier Roca* (2016) Noncanonical registers and base pairs in human 5’ splice-site selection. Nucleic Acids Res, 44, 3980-21