Wan Jun Chung, Brahim Heddi, Emmanuelle Schmitt, Kah Wai Lim, Yves Mechulam, Anh Tuan Phan
Source: Proc Natl Acad Sci U S A. 112(9):2729-33. doi: 10.1073/pnas.1418718112.
Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex (or G4). Such a structure has been implicated in cellular processes and found potential applications in therapeutics and nanotechnology.The G4 structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Using NMR and X-ray crystallography, we discovered an unprecedented left-handed DNA G4, containing structural features that can be exploited as unique recognition elements.
NTU Author contact:
Dr Anh Tuan Phan (email@example.com)
Nanyang Technological University, School of Physical and Mathematical Sciences