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Structure of a left-handed DNA G-quadruplex

Published on : 18-Mar-2015

‚Äčleft-handed DNA G-quadruplex.png

Wan Jun Chung, Brahim Heddi, Emmanuelle Schmitt, Kah Wai Lim, Yves Mechulam, Anh Tuan Phan Source: Proc Natl Acad Sci U S A. 112(9):2729-33. doi: 10.1073/pnas.1418718112. Published: 2015

Abstract:

Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex (or G4). Such a structure has been implicated in cellular processes and found potential applications in therapeutics and nanotechnology.The G4 structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Using NMR and X-ray crystallography, we discovered an unprecedented left-handed DNA G4, containing structural features that can be exploited as unique recognition elements.

NTU Author contact:

Dr Anh Tuan Phan (phantuan@ntu.edu.sg)

Nanyang Technological University, School of Physical and Mathematical Sciences